Publication Name	World Journal of Gastroenterology
Manuscript ID	5648
Country	United Kingdom

Received	2013-09-19 09:05
Peer-Review Started	2013-09-19 18:08
To Make the First Decision	2013-10-14 21:27
Return for Revision	2013-10-20 20:24
Revised	2013-10-25 07:44
Second Decision	2013-12-03 21:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-04 06:40
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-27 13:38
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Ajith K Siriwardena
Funding Agency and Grant Number
Corresponding Author	Ajith K Siriwardena, MD, FRCS, Professor, Hepatobiliary Surgery Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. ajith.siriwardena@cmft.nhs.uk
Key Words	Chronic pancreatitis; Cellular injury; Oxidative stress; Xenobiotics; Cytochrome P450
Core Tip	This review systematically appraises the evidence for the key components of the hypothesis of environmental xenobiotic exposure leading to induction of the cytochrome P450 (CYP) system in the pancreatic acinar cell and in turn compromising the free radical quenching pathway in chronic pancreatitis. The central components of the hypothesis of xenobiotic-induced, micronutrient-deficient oxidative-stress mediated cell injury in chronic pancreatitis: xenobiotic exposure causing CYP induction, acinar CYP induction and hepatocyte mediated CYP by-products causing acinar injury by bile reflux do not withstand objective scrutiny.
Publish Date	2014-03-18 14:14
Citation	Siriwardena AK. Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: A systematic review. World J Gastroenterol 2014; 20(11): 3033-3043
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/3033.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.3033

Full Article (PDF)	WJG-20-3033.pdf
Full Article (Word)	WJG-20-3033.doc
Manuscript File	5648-Review.docx
Answering Reviewers	5648-Answering reviewers.pdf
Copyright License Agreement	5648-Copyright assignment.pdf
Peer-review Report	5648-Peer reviewer(s).pdf
Scientific Editor Work List	5648-Scientific editor work list.doc