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Articles Published Processes
9/22/2020 3:17:13 AM | Browse: 486 | Download: 742
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Received |
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2020-05-06 17:10 |
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Peer-Review Started |
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2020-05-06 17:11 |
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To Make the First Decision |
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Return for Revision |
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2020-05-15 16:32 |
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Revised |
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2020-05-29 12:19 |
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Second Decision |
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2020-08-24 13:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-08-26 00:24 |
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Articles in Press |
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2020-08-26 00:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-09-16 00:59 |
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Publish the Manuscript Online |
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2020-09-22 03:17 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
From infections to autoimmunity: Diagnostic challenges in common variable immunodeficiency
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ewa Więsik-Szewczyk and Karina Jahnz-Rózyk |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ewa Więsik-Szewczyk, MD, PhD, Doctor, Department of Internal Medicine, Pulmonology, Allergy and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, Szaserów 128, Warsaw 04-141, Poland. ewa.w.szewczyk@gmail.com |
| Key Words |
Primary antibody deficiency; Recurrent respiratory tract infections; Complications; Immunoglobulin replacement; Adults; Early diagnosis |
| Core Tip |
Common variable immunodeficiency has to be considered in adults with recurrent respiratory tract infections, bronchiectasis, cytopenia, generalized lymphadenopathy, sarcoid-like symptoms, colitis in whom other conditions were excluded. Low calculated globulin, which is the difference between total protein and albumin levels, suggests hypogammaglobulinemia. Patient with common variable immunodeficiency are referred for commencing replacement immunoglobulin therapy, which should be continued regularly throughout life. It can be administered intravenously, subcutaneously and via the hyaluronidase-facilitated subcutaneous route. One must bear in mind that in patients with hypogammaglobulinemia and those treated with polyclonal immunoglobulin G products, serological tests based on determination of antibodies are unreliable. |
| Publish Date |
2020-09-22 03:17 |
| Citation |
Więsik-Szewczyk E, Jahnz-Różyk K. From infections to autoimmunity: Diagnostic and therapeutic challenges in common variable immunodeficiency. World J Clin Cases 2020; 8(18): 3942-3955 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i18/3942.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i18.3942 |
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