Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	5665
Country	Germany

Received	2013-09-20 11:30
Peer-Review Started	2013-09-20 22:43
To Make the First Decision	2013-10-14 14:19
Return for Revision	2013-10-20 23:19
Revised	2013-10-21 01:36
Second Decision	2013-12-10 16:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-12-11 09:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-14 02:48
Typeset the Manuscript	2014-01-14 15:45
Publish the Manuscript Online	2014-01-15 10:25

ISSN	1948-5204 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Antidepressant fluoxetine and its potential against colon tumors
Manuscript Source	Invited Manuscript
All Author List	Helga Stopper, Sergio Britto Garcia, Ana Maria Waaga-Gasser and Vinicius Kannen
Funding Agency and Grant Number	Funding Agency Grant Number German Academic Exchange Service (DAAD) National Council for Scientific and Technological Development (CNPQ) Foundation for Research Support of the State of São Paulo (FAPESP)
Corresponding Author	Vinicius Kannen, PhD, Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D-97078 Wuerzburg, Germany. vinicius.cardoso@uni-wuerzburg.de
Key Words	Fluoxetine; Colon cancer; Cancer therapy; Tumor metabolism
Core Tip	It is currently thought that aerobic glycolysis is key for understanding cell survival in the hostile tumor microenvironment. Then, the antidepressant fluoxetine (FLX) has been shown to reduce colon tumor growth in animals and colon cancer incidence in humans. Here, we explore new perspectives of FLX reducing the development of colon tumors through a blockage in tumor metabolism. This perspective review is based on our current unpublished experimental dataset which shows FLX as a potential co-chemotherapeutic agent for colon cancer therapy.
Publish Date	2014-01-15 10:25
Citation	Stopper H, Garcia SB, Waaga-Gasser AM, Kannen V. Antidepressant fluoxetine and its potential against colon tumors. World J Gastrointest Oncol 2014; 6(1): 11-21
URL	http://www.wjgnet.com/1948-5204/full/v6/i1/11.htm
DOI	http://dx.doi.org/10.4251/wjgo.v6.i1.11

Full Article (PDF)	WJGO-6-1.pdf
Full Article (Word)	WJGO-6-1.doc
Manuscript File	5665-Review.docx
Answering Reviewers	5665-Answering reviewers.pdf
Copyright License Agreement	5665-Copyright assignment.pdf
Peer-review Report	5665-Peer reviewer(s).pdf
Scientific Editor Work List	5665-Scientific editor work list.doc