| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Zhao, Fei Feng, Qing-Hong Guo, Yu-Ping Wang and Rui Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Program of Gansu Province Grant |
18JR3RA339 |
| Science and Technology Program of Gansu Province Grant |
18JR3RA363 |
| Fund of the First Hospital of Lanzhou University Grant |
ldyyyn2018-63 |
| Teaching and Research Project of the First Clinical Medical College of Lanzhou University in 2018 Grant |
2018007 |
| NIH awards |
R21NS106430 |
| NIH awards |
R01OD026594 |
| Cystic Fibrosis Foundation Research Grant |
ZHAO19G0 |
| an American Cancer Society-IRG Junior Faculty Development Grant, a UAB CCC Neuro-oncology Research Acceleration Grant, and a UAB Faculty Development Grant Program Award |
|
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| Corresponding Author |
Yue Zhao, MD, Doctor, Doctor, Department of Gastroenterology, the First Hospital of Lanzhou University, Key Laboratory for Gastrointestinal Disease of Gansu Province, No. 1 Donggaung West Road, Lanzhou 730000, Gansu Province, China. ldyy_yzhao@lzu.edu.cn |
| Key Words |
Gastrointestinal stromal tumors; Succinate dehydrogenase; Oncometabolite; Succinate; α-ketoglutarate-dependent dioxygenase; Epigenetics |
| Core Tip |
The connection between altered cellular metabolism and tumorigenesis has gained increased attention in recent years. Deficiency in succinate dehydrogenase (SDH), a key metabolic enzyme, drives tumorigenesis of a subset of gastrointestinal stromal tumors (GISTs) by accumulating the oncometabolite succinate. Oncometabolites such as succinate, D-2-hydroxyglutarate, and fumarate competitively inhibit the α-ketoglutarate-dependent dioxygenase family enzymes, which regulate epigenetic status, hypoxia responses, RNA metabolism, and DNA damage repair. In this article, we review the recent advances in understanding how metabolic enzyme mutations and oncometabolites drive human cancer with an emphasis on the SDH deficiency and succinate in GISTs. |
| Publish Date |
2020-09-09 11:11 |
| Citation |
Zhao Y, Feng F, Guo QH, Wang YP, Zhao R. Role of Succinate Dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors. World J Gastroenterol 2020; 26(34): 5074-5089 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i34/5074.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i34.5074 |
