| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michelle Liz de Souza Pessoa, Leiliane Macena Oliveira Silva, Maria Elaine Cristina Araruna, Catarina Alves de Lima Serafim, Edvaldo Balbino Alves Júnior, Alessa Oliveira Silva, Matheus Marley Bezerra Pessoa, Hermes Diniz Neto, Edeltrudes de Oliveira Lima and Leônia Maria Batista |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Leônia Maria Batista, PharmD, Associate Professor, Professor, Postgraduate Program in Natural and Synthetic Bioactive Products, Universidade Federal da Paraiba, Cidade Universitária, s/n - Castelo Branco III, João Pessoa 58051-900, Brazil. leoniab@uol.com.br |
| Key Words |
(-)-Fenchone; Monoterpenes; Diarrhea; Motility; Antifungal; |
| Core Tip |
(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species, such as Foeniculum vulgare and Peumus boldus, used to treatment of gastrointestinal diseases. Diarrhea is a pathological condition characterized by an increase in three or more defecations in 24 h, being of multiple origins, whether infectious or not. In the search for new therapeutic alternatives, natural products, and medicinal plants are of great relevance. Many species of plants and their isolated compounds, including terpenes, have shown promising antidiarrheal and motility, based on this result, the monoterpene (-)-fenchone was selected for this study. |
| Publish Date |
2020-11-20 04:04 |
| Citation |
Pessoa MLS, Silva LMO, Araruna MEC, Serafim CAL, Alves Júnior EB, Silva AO, Pessoa MMB, Diniz Neto H, de Oliveira Lima E, Batista LM. Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models. World J Gastroenterol 2020; 26(43): 6795-6809 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i43/6795.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i43.6795 |
