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Articles Published Processes
11/26/2020 10:14:32 AM | Browse: 708 | Download: 1451
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Received |
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2020-06-01 08:20 |
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Peer-Review Started |
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2020-05-28 11:36 |
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To Make the First Decision |
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Return for Revision |
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2020-07-30 23:40 |
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Revised |
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2020-07-31 13:11 |
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Second Decision |
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2020-09-01 07:09 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-01 20:27 |
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Articles in Press |
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2020-09-01 20:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-24 03:16 |
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Typeset the Manuscript |
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2020-11-25 06:02 |
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Publish the Manuscript Online |
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2020-11-26 10:14 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Basic Study |
| Article Title |
Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nataliya Petinati, Nikolay Kapranov, Yulia Davydova, Alexey Bigildeev, Olesya Pshenichnikova, Dmitriy Karpenko, Nina Drize, Larisa Kuzmina, Elena Parovichnikova and Valeriy Savchenko |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Foundation for Basic Research |
19-29-04023 |
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| Corresponding Author |
Nina Drize, PhD, Professor, Laboratory for Physiology of Hematopoiesis, National Research Center for Hematology, Noviy Zykovskiy, 4, Moscow 125167, Russia. drize.n@blood.ru |
| Key Words |
Multipotent mesenchymal stromal cells; Acute graft vs host disease; Immunophenotype; Lymphocytes; Immunomodulation; Pro-inflammatory cytokines |
| Core Tip |
An attempt was made to identify the main differences between multipotent mesenchymal stromal cells (MSCs) samples that are effective and those that are ineffective in preventing the development of acute graft vs host disease after allogeneic bone marrow transplantation. The mean fluorescence intensity of HLA-ABC, HLA-DR, CD105, and CD146 was shown to be significantly lower on the surface of samples that were ineffective for prophylaxis. Significant differences were revealed between effective and ineffective MSCs in terms of their responses to interaction with lymphocytes and stimulation by pro-inflammatory cytokines. The patterns observed here indicate a possible mechanism of the immunosuppressive action of these cells in clinical use. |
| Publish Date |
2020-11-26 10:14 |
| Citation |
Petinati N, Kapranov N, Davydova Y, Bigildeev A, Pshenichnikova O, Karpenko D, Drize N, Kuzmina L, Parovichnikova E, Savchenko V. Immunophenotypic characteristics of multipotent mesenchymal stromal cells that affect the efficacy of their use in the prevention of acute graft vs host disease. World J Stem Cells 2020; 12(11): 1377-1395 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i11/1377.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i11.1377 |
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