Publication Name	World Journal of Gastroenterology
Manuscript ID	5718
Country	Italy

Received	2013-09-23 09:23
Peer-Review Started	2013-09-24 09:18
To Make the First Decision	2013-12-26 10:58
Return for Revision	2013-12-26 16:00
Revised
Second Decision	2014-04-23 08:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 09:59
Articles in Press	2014-05-23 10:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-04 15:01
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Possible biological and translational significance of mast cells density in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Ilaria Marech, Michele Ammendola, Claudia Gadaleta, Nicola Zizzo, Caroline Oakley, Cosmo Damiano Gadaleta and Girolamo Ranieri
Funding Agency and Grant Number
Corresponding Author	Girolamo Ranieri, MD, Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre Istituto Tumori “Giovanni Paolo Ⅱ”, Via Orazio Flacco 65, 70124 Bari, Italy. giroran@tiscalinet.it
Key Words	Tryptase; Mast cell density; Proteinase-activated receptor-2; c-Kit receptor; Vascular endothelial growth factor; Angiogenesis; Colorectal cancer; Tumor progression; Tryptase inhibitors; c-Kit receptor tyrosine kinase inhibitors
Core Tip	In several malignancies it has been well demonstrated that mast cell (MC), activated c-Kit receptor (c-KitR) and tryptase secreted after MC degranulation play a pivotal role in tumor angiogenesis, helping tumor cell invasion and metastasis. The close relationship between MC density, angiogenesis and tumor progression could suggest a role for MCs as a possible prognostic factor in colorectal cancer (CRC). Moreover, considering MC-mediated CRC development, c-KitR tyrosine kinase inhibitors (imatinib, masitinib) and tryptase inhibitors (gabexate and nafamostat mesylate) could be used to block MC activation/degranulation and the tryptase/proteinase-activated receptor-2 axis respectively, and may be evaluated in future clinical trials in CRC patients.
Publish Date	2014-07-21 17:17
Citation	Marech I, Ammendola M, Gadaleta C, Zizzo N, Oakley C, Gadaleta CD, Ranieri G. Possible biological and translational significance of mast cells density in colorectal cancer. World J Gastroenterol 2014; 20(27): 8910-8920
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/8910.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.8910

Full Article (PDF)	WJG-20-8910.pdf
Full Article (Word)	WJG-20-8910.doc
Manuscript File	5718-Review.docx
Answering Reviewers	5718-Answering reviewers.pdf
Copyright License Agreement	5718-Copyright assignment.pdf
Peer-review Report	5718-Peer reviews.pdf
Scientific Editor Work List	5718-Scientific editor work list.doc