Publication Name	World Journal of Stem Cells
Manuscript ID	57237
Country	France

Received	2020-05-29 12:36
Peer-Review Started	2020-05-29 12:37
To Make the First Decision
Return for Revision	2020-06-15 18:26
Revised	2020-06-26 13:57
Second Decision	2020-08-24 13:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-25 05:26
Articles in Press	2020-08-25 05:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-08-30 19:55
Typeset the Manuscript	2020-10-23 07:50
Publish the Manuscript Online	2020-10-26 12:01

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Engineering, Biomedical
Manuscript Type	Review
Article Title	Urine-derived stem/progenitor cells: A focus on their characterization and potential
Manuscript Source	Invited Manuscript
All Author List	Perrine Burdeyron, Sébastien Giraud, Thierry Hauet and Clara Steichen
ORCID	Author(s) ORCID Number Perrine Burdeyron http://orcid.org/0000-0001-8301-2717 Sébastien Giraud http://orcid.org/0000-0001-9015-8968 Thierry Hauet http://orcid.org/0000-0002-0117-071X Clara Steichen http://orcid.org/0000-0003-1201-4904
Funding Agency and Grant Number	Funding Agency Grant Number Institut National de la Santé et la Recherche Médicale Université de Poitiers; CHU de Poitiers Région Nouvelle Aquitaine; Fondation de l’Avenir AP-RM-18-006
Corresponding Author	Clara Steichen, MSc, PhD, Postdoctoral Fellow, INSERM U1082 IRTOMIT, CHU de Poitiers, 2 rue de la Milétrie, Poitiers 86021, France. clara.steichen@inserm.fr
Key Words	Urine-derived stem cells; Urine progenitor cells; Exosomes; Cell therapy; Kidney injury and repair; Regenerative medicine
Core Tip	Urine-derived stem cells (USCs) aroused interest in the past years and display classical features of mesenchymal stem cells such as differentiation capacity and immunomodulation. Importantly, they have the main advantage of being isolable from one sample of voided urine. Moreover, USCs can be differentiated into many cell types including renal cells, this being of high interest for renal cell therapy-based regenerative approaches. This review will firstly describe the isolation and characterization of USCs and detail their differentiation capacity. Then, we will present the main applications of USCs, from reprogramming into human induced pluripotent stem cells to their use for cell therapy approaches (either directly or via their exosomes). Finally, the remaining barriers and challenges in the field of USC-based regenerative medicine will be discussed.
Publish Date	2020-10-26 12:01
Citation	Burdeyron P, Giraud S, Hauet T, Steichen C. Urine-derived stem/progenitor cells: A focus on their characterization and potential. World J Stem Cells 2020; 12(10): 1080-1096
URL	https://www.wjgnet.com/1948-0210/full/v12/i10/1080.htm
DOI	https://dx.doi.org/10.4252/wjsc.v12.i10.1080

Full Article (PDF)	WJSC-12-1080.pdf
Full Article (Word)	WJSC-12-1080.docx
Manuscript File	57237-Review-Filipodia.docx
Answering Reviewers	57237-Answering reviewers.pdf
Audio Core Tip	57237-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	57237-Conflict-of-interest statement.pdf
Copyright License Agreement	57237-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	57237-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	57237-Language certificate.pdf
Peer-review Report	57237-Peer-review(s).pdf
Scientific Misconduct Check	57237-Scientific misconduct check.pdf
Scientific Editor Work List	57237-Scientific editor work list.pdf
CrossCheck Report	57237-CrossCheck report.pdf