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Articles Published Processes
11/24/2020 12:41:21 PM | Browse: 582 | Download: 1262
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Received |
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2020-06-12 08:52 |
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Peer-Review Started |
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2020-06-11 21:22 |
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To Make the First Decision |
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Return for Revision |
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2020-07-30 23:33 |
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Revised |
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2020-08-15 17:53 |
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Second Decision |
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2020-09-17 13:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-09-18 20:27 |
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Articles in Press |
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2020-09-18 20:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-24 02:27 |
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Typeset the Manuscript |
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2020-11-16 00:38 |
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Publish the Manuscript Online |
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2020-11-24 12:41 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Martin Franck, Cosima Thon, Kerstin Schütte, Peter Malfertheiner and Alexander Link |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alexander Link, MD, PhD, Academic Research, Associate Professor, Doctor, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Street 44, Magdeburg 39120, Germany. alexander.link@med.ovgu.de |
| Key Words |
Hepatocellular cancer; Hepatocellular carcinoma; MicroRNA; Prognosis; miR-21-5p; Renal function |
| Core Tip |
In our previous work, we identified renal function, hemoglobin and liver injury as potential factors that may impact circulating micro ribonucleic acid expression. miR-21-5p is the most frequently deregulated micro ribonucleic acid in various types of cancer. Several reports have proposed miR-21-5p as prognostic biomarker in hepatocellular carcinoma. In this study, serum miR-21-5p values were not associated with prognosis of hepatocellular carcinoma in European cohort of patients with predominantly alcohol-related liver injury. In similar fashion as previously reported for miR-122-5p, changes in circulating miR-21-5p level correlated with renal function and liver injury. This observation provides cautionary remarks on interpretation of circulating miR-21-5p level and its biomarker potential. |
| Publish Date |
2020-11-24 12:41 |
| Citation |
Franck M, Thon C, Schütte K, Malfertheiner P, Link A. Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function. World J Hepatol 2020; 12(11): 1031-1045 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i11/1031.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i11.1031 |
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