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9/28/2020 1:45:47 AM | Browse: 470 | Download: 699
Publication Name World Journal of Clinical Cases
Manuscript ID 57326
Country/Territory China
Received
2020-06-04 01:49
Peer-Review Started
2020-06-04 01:50
To Make the First Decision
Return for Revision
2020-07-25 04:11
Revised
2020-07-30 09:42
Second Decision
2020-08-28 12:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-29 02:00
Articles in Press
2020-08-29 02:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-09-02 00:50
Typeset the Manuscript
2020-09-24 09:51
Publish the Manuscript Online
2020-09-28 01:45
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Public, Environmental & Occupational Health
Manuscript Type Case Control Study
Article Title Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis
Manuscript Source Unsolicited Manuscript
All Author List Mian Wang, Shu-Juan Ma, Xin-Yin Wu, Xian Zhang, Julius Abesig, Zheng-Hui Xiao, Xin Huang, Hai-Peng Yan, Jing Wang, Meng-Shi Chen and Hong-Zhuan Tan
ORCID
Author(s) ORCID Number
Mian Wang http://orcid.org/0000-0002-9285-7153
Shu-Juan Ma http://orcid.org/0000-0002-7858-067X
Xin-Yin Wu http://orcid.org/0000-0003-3772-2376
Xian Zhang http://orcid.org/0000-0003-4079-9470
Julius Abesig http://orcid.org/0000-0002-0061-8244
Zheng-Hui Xiao http://orcid.org/0000-0002-2466-1124
Xin Huang http://orcid.org/0000-0002-4874-3626
Hai-Peng Yan http://orcid.org/0000-0003-1913-0959
Jing Wang http://orcid.org/0000-0002-4517-0594
Meng-Shi Chen http://orcid.org/0000-0002-9100-0967
Hong-Zhuan Tan http://orcid.org/0000-0002-4292-5947
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (General Program) 81803298
Hunan Provincial Natural Science Foundation of China 2020JJ4762
Corresponding Author Meng-Shi Chen, PhD, Lecturer, Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, No. 110 Xiangya Road, Changsha 410078, Hunan Province, China. 121444639@qq.com
Key Words Tuberculosis; mTOR; Tea drinking; Gene-environment interaction; The relative excess risk of interaction; Single nucleotide polymorphism
Core Tip Our data demonstrated that genotypes GT, GG, and GT + GG at rs2295080; genotypes CT and CT + TT at rs2024627; genotypes CT, CC and CT + CC at rs1057079; and genotypes CT and CT + CC at rs7525957 of mTOR gene are associated with statistically increased risk of tuberculosis in a Chinese population. In addition, there was a negative interaction between each of the four single nucleotide polymorphism (SNPs) and tea drinking. These findings may be helpful for identifying high-risk populations of tuberculosis, and suggest that promoting tea drinking might be a new way to reduce the risk of tuberculosis for individuals with mutations in the four SNPs.
Publish Date 2020-09-28 01:45
Citation Wang M, Ma SJ, Wu XY, Zhang X, Abesig J, Xiao ZH, Huang X, Yan HP, Wang J, Chen MS, Tan HZ. Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis. World J Clin Cases 2020; 8(19): 4320-4330
URL https://www.wjgnet.com/2307-8960/full/v8/i19/4320.htm
DOI https://dx.doi.org/10.12998/wjcc.v8.i19.4320
Full Article (PDF) WJCC-8-4320.pdf
Full Article (Word) WJCC-8-4320.docx
STROBE Statement 57326-STROBE-Statement-revision.pdf
Manuscript File 57326-Review-Ma JY.docx
Answering Reviewers 57326-Answering reviewers.pdf
Audio Core Tip 57326-Audio core tip.MP3
Biostatistics Review Certificate 57326-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 57326-Conflict-of-interest statement.pdf
Copyright License Agreement 57326-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 57326-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 57326-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 57326-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 57326-Language certificate.pdf
Peer-review Report 57326-Peer-review(s).pdf
Scientific Misconduct Check 57326-Bing-Wang JL-1.jpg
Scientific Misconduct Check 57326-Scientific misconduct check.pdf
Scientific Editor Work List 57326-Scientific editor work list.pdf