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Articles Published Processes
1/26/2021 4:22:54 PM | Browse: 633 | Download: 1558
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Received |
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2020-07-31 01:31 |
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Peer-Review Started |
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2020-07-31 01:32 |
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To Make the First Decision |
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Return for Revision |
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2020-10-23 21:12 |
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Revised |
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2020-11-09 02:23 |
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Second Decision |
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2020-11-17 09:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-17 22:40 |
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Articles in Press |
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2020-11-17 22:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-23 21:21 |
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Typeset the Manuscript |
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2021-01-24 03:40 |
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Publish the Manuscript Online |
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2021-01-26 16:22 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Joice Teixeira de Bitencorte, Tássia Flores Rech, Vagner Ricardo Lunge, Deivid Cruz dos Santos, Mário Reis Álvares-da-Silva and Daniel Simon |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
001 |
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| Corresponding Author |
Daniel Simon, PhD, Adjunct Professor, PPG Biologia Celular e Molecular Aplicada à Saúde, Universidade Luterana do Brasil, Av. Farroupilha, 8001 – Prédio 22 – 5° andar, Canoas 92425-900, Rio Grande do Sul, Brazil. daniel.simon@ulbra.br |
| Key Words |
Hepatitis C; Hepatitis C virus; Cirrhosis; Hepatocellular carcinoma; Genetic polymorphism; Interferon-lambda |
| Core Tip |
Hepatitis C virus (HCV) infection is a major public health problem worldwide as the infection progresses to severe chronic liver diseases in many patients. Nevertheless, the occurrence of different clinical manifestations can be influenced by human genetic polymorphisms. Interferon lambdas modulate the immune responses against infections, including the antiviral activity by promoting the expression of several genes related to immunological functions. The interferon lambda-4 rs12979860 (C/T) polymorphism, which is associated with spontaneous and treatment-induced clearance of HCV, plays a pivotal role in the host response to HCV-associated liver diseases. In this case-control study, the rs12979860 T allele was found to be associated with the development of cirrhosis and hepatocellular carcinoma in chronic HCV-infected patients. |
| Publish Date |
2021-01-26 16:22 |
| Citation |
de Bitencorte JT, Rech TF, Lunge VR, dos Santos DC, Álvares-da-Silva MR, Simon D. Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection. World J Hepatol 2021; 13(1): 109-119 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i1/109.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i1.109 |
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