Publication Name	World Journal of Gastroenterology
Manuscript ID	5749
Country	Singapore

Received	2013-09-25 09:48
Peer-Review Started	2013-09-25 14:44
To Make the First Decision	2013-10-14 21:13
Return for Revision	2013-10-16 13:19
Revised	2013-10-29 19:33
Second Decision	2014-01-06 18:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-06 18:58
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-20 09:54
Publish the Manuscript Online	2014-02-17 14:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Second and third line treatment options for Helicobacter pylori eradication
Manuscript Source	Invited Manuscript
All Author List	Mingjun Song and Tiing Leong Ang
Funding Agency and Grant Number
Corresponding Author	Tiing Leong Ang, MBBS, MRCP (UK), FRCP Edin, Associate Professor, Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore. tiing_leong_ang@cgh.com.sg
Key Words	Helicobacter pylori; Treatment failure; Salvage therapy; Drug resistance; Microbial; Bismuth; Ofloxacin; Moxifloxacin; Metronidazole; Rifabutin; Rifaximin; Sitafloxacin
Core Tip	The reasons for treatment failure in Helicobacter pylori eradication need not always be due to antibiotic resistance; compliance to therapy and duration should always be evaluated. Choice of therapy need not strictly adhere to guidelines; clinicians should first explore the antibiotic resistance prevalence in their treatment population if possible. Third line therapy generally shows better eradication if it was based on antibiotic susceptibility tests, but this can be time-consuming and more costly. Empirical third-line therapies have yet to show satisfactory eradication rates although most studies generally have smaller study populations.
Publish Date	2014-02-17 14:01
Citation	Song M, Ang TL. Second and third line treatment options for Helicobacter pylori eradication. World J Gastroenterol 2014; 20(6): 1517-1528
URL	http://www.wjgnet.com/1007-9327/full/v20/i6/1517.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i6.1517

Full Article (PDF)	WJG-20-1517.pdf
Full Article (Word)	WJG-20-1517.doc
Manuscript File	5749-Review.docx
Answering Reviewers	5749-Answering reviewers.pdf
Copyright License Agreement	5749-Copyright assignment.pdf
Peer-review Report	5749-Peer reviews.pdf
Scientific Editor Work List	5749-Scientific editor work list.doc