Publication Name	World Journal of Gastroenterology
Manuscript ID	5753
Country	Italy

Received	2013-09-25 10:29
Peer-Review Started	2013-09-25 16:21
First Decision by Editorial Office Director
Return for Revision	2013-11-22 08:56
Revised	2013-12-03 18:58
Publication Fee Transferred
Second Decision by Editor	2014-01-15 20:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-01-15 20:36
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-19 11:58
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Telomeres, telomerase and colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Roberta Bertorelle, Enrica Rampazzo, Salvatore Pucciarelli, Donato Nitti and Anita De Rossi
Funding Agency and Grant Number
Corresponding Author	Anita De Rossi, PhD, Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy. anita.derossi@unipd.it
Key Words	Telomere; Telomerase; Telomerase reverse transcriptase; Colorectal cancer; Prognostic marker
Core Tip	Telomere/telomerase interplay is an important mechanism involved in both genomic stability and cellular replicative potential. Telomere shortening is an early event that contributes to genetic instability, which plays a key role in the early steps of carcinogenesis. The activation of telomerase, which preserves replicative potential by maintaining the length of telomeres, occurs during the adenoma-carcinoma sequence and increases during tumour progression. While the prognostic value of telomere length is controversial, most studies agree that the level of telomerase in tumours represents a useful prognostic marker. Circulating telomerase reverse transcriptase is a promising marker for the minimally invasive monitoring of disease and response to therapy.
Publish Date	2014-02-26 11:18
Citation	Bertorelle R, Rampazzo E, Pucciarelli S, Nitti D, De Rossi A. Telomeres, telomerase and colorectal cancer. World J Gastroenterol 2014; 20(8): 1940-1950
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/1940.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.1940

Full Article (PDF)	WJG-20-1940.pdf
Full Article (Word)	WJG-20-1940.doc
Manuscript File	5753-Review.docx
Answering Reviewers	5753-Answering reviewers.pdf
Copyright License Agreement	5753-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5753-Language certificate.pdf
Peer-review Report	5753-Peer reviews.pdf
Scientific Editor Work List	5753-Scientific editor work list.doc