| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Real impact of tumor marker AFP and PIVKA-Ⅱ in detecting very small hepatocellular carcinoma (≤ 2 cm, Barcelona stage 0) - assessment with large number of cases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kazuo Tarao, Akito Nozaki, Hirokazu Komatsu, Tatsuji Komatsu, Masataka Taguri, Katsuaki Tanaka, Makoto Chuma, Kazushi Numata and Shin Maeda |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Kanagawa Association of Medical and Dental Practitioners |
|
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| Corresponding Author |
Kazuo Tarao, MD, PhD, Director, Director, Department of Gastroenterology, Tarao’s Gastroenterological Clinic, 2-58-6, Taiyo Building Futamatagawa, Asahi-ku, Yokohama 241-0821, Japan. duoluoweih7@gmail.com |
| Key Words |
Hepatocellular carcinoma; AFP; PIVKA-Ⅱ; Barcelona clinical stage; Tumor markers; |
| Core Tip |
In hepatocellular carcinoma, detection and treatment prior to growth 2 cm (Barcelona stage 0) are relevant as a larger tumor size is more frequently associated with microvascular invasion and / or satellites. We surveyed the real impact of the tumor markers AFP or PIVKA-Ⅱ in detecting very small hepatocellular carcinoma with a large number of cases (≤ 2 cm in diameter 394 cases), and found that in AFP 50.5% and in PIVKA-Ⅱ 68.8% showed normal levels. Moreover, 36.4% of the patients showed normal levels in both AFP and PIVKA-Ⅱ. In the surveillance of very small hepatocellular carcinoma nodules the tumor markers are not so useful. |
| Publish Date |
2020-11-24 12:41 |
| Citation |
Tarao K, Nozaki A, Komatsu H, Komatsu T, Taguri M, Tanaka K, Chuma M, Numata K, Maeda S. Real impact of tumor marker AFP and PIVKA-Ⅱ in detecting very small hepatocellular carcinoma (≤ 2 cm, Barcelona stage 0) - assessment with large number of cases. World J Hepatol 2020; 12(11): 1046-1054 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i11/1046.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i11.1046 |
