Publication Name	World Journal of Biological Chemistry
Manuscript ID	57637
Country	United States

Received	2020-06-17 15:49
Peer-Review Started	2020-06-17 15:50
To Make the First Decision
Return for Revision	2020-07-21 16:17
Revised	2020-07-24 19:49
Second Decision	2020-08-25 09:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-26 04:40
Articles in Press	2020-08-26 04:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-09-08 11:31
Publish the Manuscript Online	2020-09-24 09:16

ISSN	1949-8454 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Respiratory System
Manuscript Type	Review
Article Title	Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity
Manuscript Source	Invited Manuscript
All Author List	Indiwari Gopallawa and Robert J Lee
ORCID	Author(s) ORCID Number Indiwari Gopallawa http://orcid.org/0000-0001-9498-1863 Robert J Lee http://orcid.org/0000-0001-5826-6686
Funding Agency and Grant Number	Funding Agency Grant Number The United States National Institutes of Health R01DC016309 The United States Cystic Fibrosis Foundation GOPALL19F0
Corresponding Author	Robert J Lee, PhD, Assistant Professor, Department of Otorhinolaryngology and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5th Floor Ravdin, Suite A, Philadelphia, PA 19104, United States. rjl@pennmedicine.upenn.edu
Key Words	Lung; Nitric oxide synthase; Nuclear factor erythroid 2 related factor-2; Respiratory infections; Cystic fibrosis;
Core Tip	The human respiratory epithelium is continuously exposed to pathogens during each inhalation. Protection of the lung depends on complex signaling networks that activate host defense mechanisms. The kinase Akt interacts with numerous cellular proteins involved in airway innate immunity. In this review, we discuss the Akt pathway and known downstream targets involved in airway innate immunity.
Publish Date	2020-09-24 09:16
Citation	Gopallawa I, Lee RJ. Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity. World J Biol Chem 2020; 11(2): 30-51
URL	https://www.wjgnet.com/1949-8454/full/v11/i2/30.htm
DOI	https://dx.doi.org/10.4331/wjbc.v11.i2.30

Full Article (PDF)	WJBC-11-30.pdf
Full Article (Word)	WJBC-11-30.docx
Manuscript File	57637-Review.docx
Answering Reviewers	57637-Answering reviewers.pdf
Audio Core Tip	57637-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	57637-Conflict-of-interest statement.pdf
Copyright License Agreement	57637-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	57637-Grant application form(s).pdf
Peer-review Report	57637-Peer-review(s).pdf
Scientific Misconduct Check	57637-Scientific misconduct check.pdf
Scientific Editor Work List	57637-Scientific editor work list.pdf
CrossCheck Report	57637-CrossCheck Report.pdf