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Articles Published Processes
11/13/2020 6:52:32 AM | Browse: 667 | Download: 1932
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Received |
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2020-06-26 08:03 |
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Peer-Review Started |
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2020-06-26 08:03 |
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To Make the First Decision |
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Return for Revision |
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2020-08-22 21:48 |
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Revised |
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2020-08-27 05:34 |
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Second Decision |
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2020-09-22 10:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-22 20:35 |
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Articles in Press |
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2020-09-22 20:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-11-12 02:15 |
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Publish the Manuscript Online |
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2020-11-13 06:52 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yuri Cho, Min Ji Park, Koeun Kim, Sun Woong Kim, Wonjin Kim, Sooyeon Oh and Joo Ho Lee |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea grant funded by the Korea government |
2018R1C1B6001102 |
| Research Supporting Program of the Korean Association for the Study of the Liver and The Korean Liver Foundation |
year: 2017 |
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| Corresponding Author |
Yuri Cho, MD, PhD, Assistant Professor, Department of Internal Medicine, CHA Gangnam Medical Center, CHA University School of Medicine, No. 569 Nonhyon-ro, Gangnam-gu, Seoul 06135, South Korea. yuricho@cha.ac.kr |
| Key Words |
Hepatocellular carcinoma; Yes-associated protein-1; C-Myc; Reactive oxygen species; Unfolded protein response; Activating transcription factor-6 |
| Core Tip |
We found a novel connection between yes-associated protein-1 (YAP-1) and the unfolded protein response (UPR) through the c-Myc pathway during oxidative stress in hepatocellular carcinoma (HCC). As the Hippo pathway and c-Myc pathway share many important functions, including the regulation of growth, death and survival in cells and the regulation of stress resistance and life spans in organisms, we speculate that the interaction between YAP-1 and c-Myc is a point of convergence that allows HCC proliferation. The reactive oxygen species-induced activation of YAP-1 via the c-Myc pathway, which leads to the activation of the UPR pathway, might be a therapeutic target in HCC. |
| Publish Date |
2020-11-13 06:52 |
| Citation |
Cho Y, Park MJ, Kim K, Kim SW, Kim W, Oh S, Lee JH. Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma. World J Gastroenterol 2020; 26(42): 6599-6613 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i42/6599.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i42.6599 |
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