| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Review |
| Article Title |
Noninvasive in vivo cell tracking using molecular imaging: A useful tool for developing mesenchymal stem cell-based cancer treatment
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ramya Lakshmi Rajendran, Manasi Pandurang Jogalekar, Prakash Gangadaran and Byeong-Cheol Ahn |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program via the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Republic of South Korea |
NRF-2019R1I1A1A01061296 |
| Basic Science Research Program via the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Republic of South Korea |
NRF-2019R1I1A3A01063308 |
|
| Corresponding Author |
Byeong-Cheol Ahn, MD, PhD, Professor, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, 680 gukchaebosang-ro, Jung-gu, Daegu 41944, South Korea. abc2000@knu.ac.kr |
| Key Words |
Cell therapy; Mesenchymal stem cells; In vivo molecular imaging; Drug delivery; Superparamagnetic iron oxide |
| Core Tip |
There is substantial evidence that highlights the potential of cell therapies in treating various diseases including cancers. Molecular imaging has been actively used for decades in assessing cellular processes, evaluating properties of certain drugs, screening of compound libraries, and visualizing the fate of cells. This manuscript aimed to check whether noninvasive in vivo cell tracking in combination with molecular imaging could be used as a tool for the development of mesenchymal stem cell-based cancer treatment. To that end, the following aspects have been outlined in the text: labeling approaches, imaging modalities, advantages and disadvantages of each strategy, and scope and limitations of the various imaging approaches. In conclusion, together with long-term monitoring, a lot can be learned in regard to the hidden potential of MSCs as well as their variable fate in humans. |
| Publish Date |
2020-12-27 05:30 |
| Citation |
Rajendran RL, Jogalekar MP, Gangadaran P, Ahn BC. Noninvasive in vivo cell tracking using molecular imaging: A useful tool for developing mesenchymal stem cell-based cancer treatment. World J Stem Cells 2020; 12(12): 1492-1510 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i12/1492.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i12.1492 |
