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Articles Published Processes
12/18/2020 5:58:43 AM | Browse: 541 | Download: 1254
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Received |
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2020-06-30 14:21 |
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Peer-Review Started |
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2020-06-30 14:22 |
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To Make the First Decision |
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Return for Revision |
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2020-09-14 07:58 |
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Revised |
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2020-09-30 13:18 |
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Second Decision |
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2020-10-29 10:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-10-29 20:57 |
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Articles in Press |
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2020-10-29 20:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-10 07:30 |
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Typeset the Manuscript |
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2020-12-10 02:43 |
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Publish the Manuscript Online |
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2020-12-18 05:58 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sara M Atwa, Heba Handoussa, Karim M Hosny, Margarete Odenthal and Hend M El Tayebi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hend M El Tayebi, PhD, Assistant Professor, Lecturer, Pharmacist, Senior Postdoctoral Fellow, Genetic Pharmacology Research Group, Clinical Pharmacy Unit, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City - Main Entrance Al Tagamoa Al Khames, Cairo 11835, Egypt. hend.saber@guc.edu.eg |
| Key Words |
Hepatocellular carcinoma; X-inactive specific transcript; MiR-155-5p; MiR-194-5p; Programmed cell-death protein 1/Programmed death ligand 1; Immune checkpoint |
| Core Tip |
Owing to the immune rich milieu of hepatocellular carcinoma (HCC), it is a good candidate for immune based therapies. Our aim through this study was to identify potential upstream epigenetic regulators of immune checkpoint programmed cell-death protein 1/programmed death ligand 1in HCC to be regarded as therapeutic targets. The interesting findings of this study have revealed the re-questioning of the role of certain non-coding ribonucleic acid in HCC context. Here we deduced a novel shared upstream regulatory signaling pathway for programmed cell-death protein 1/programmed death ligand 1 immune checkpoint between paradoxically acting tumor suppressor miR-194-5p and onco-miR-155-5p, in HCC through X-inactive specific transcript expression modulation. |
| Publish Date |
2020-12-18 05:58 |
| Citation |
Atwa SM, Handoussa H, Hosny KM, Odenthal M, El Tayebi HM. Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma. World J Hepatol 2020; 12(12): 1211-1227 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i12/1211.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i12.1211 |
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