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12/18/2020 5:58:43 AM | Browse: 430 | Download: 842
Publication Name World Journal of Hepatology
Manuscript ID 57925
Country/Territory Egypt
Received
2020-06-30 14:21
Peer-Review Started
2020-06-30 14:22
To Make the First Decision
Return for Revision
2020-09-14 07:58
Revised
2020-09-30 13:18
Second Decision
2020-10-29 10:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-10-29 20:57
Articles in Press
2020-10-29 20:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-10 07:30
Typeset the Manuscript
2020-12-10 02:43
Publish the Manuscript Online
2020-12-18 05:58
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Sara M Atwa, Heba Handoussa, Karim M Hosny, Margarete Odenthal and Hend M El Tayebi
ORCID
Author(s) ORCID Number
Sara M Atwa http://orcid.org/0000-0002-2353-3876
Heba Handoussa http://orcid.org/0000-0001-5552-1725
Karim M Hosny http://orcid.org/0000-0002-7937-6793
Margarete Odenthal http://orcid.org/0000-0002-2424-0960
Hend M El Tayebi http://orcid.org/0000-0002-6896-6018
Funding Agency and Grant Number
Corresponding Author Hend M El Tayebi, PhD, Assistant Professor, Lecturer, Pharmacist, Senior Postdoctoral Fellow, Genetic Pharmacology Research Group, Clinical Pharmacy Unit, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City - Main Entrance Al Tagamoa Al Khames, Cairo 11835, Egypt. hend.saber@guc.edu.eg
Key Words Hepatocellular carcinoma; X-inactive specific transcript; MiR-155-5p; MiR-194-5p; Programmed cell-death protein 1/Programmed death ligand 1; Immune checkpoint
Core Tip Owing to the immune rich milieu of hepatocellular carcinoma (HCC), it is a good candidate for immune based therapies. Our aim through this study was to identify potential upstream epigenetic regulators of immune checkpoint programmed cell-death protein 1/programmed death ligand 1in HCC to be regarded as therapeutic targets. The interesting findings of this study have revealed the re-questioning of the role of certain non-coding ribonucleic acid in HCC context. Here we deduced a novel shared upstream regulatory signaling pathway for programmed cell-death protein 1/programmed death ligand 1 immune checkpoint between paradoxically acting tumor suppressor miR-194-5p and onco-miR-155-5p, in HCC through X-inactive specific transcript expression modulation.
Publish Date 2020-12-18 05:58
Citation Atwa SM, Handoussa H, Hosny KM, Odenthal M, El Tayebi HM. Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma. World J Hepatol 2020; 12(12): 1211-1227
URL https://www.wjgnet.com/1948-5182/full/v12/i12/1211.htm
DOI https://dx.doi.org/10.4254/wjh.v12.i12.1211
Full Article (PDF) WJH-12-1211.pdf
Full Article (Word) WJH-12-1211.docx
Manuscript File 57925_Auto_Edited-Webster J.docx
Answering Reviewers 57925-Answering reviewers.pdf
Audio Core Tip 57925-Audio core tip.m4a
Biostatistics Review Certificate 57925-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 57925-Conflict-of-interest statement.pdf
Copyright License Agreement 57925-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 57925-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 57925-Language certificate.pdf
Peer-review Report 57925-Peer-review(s).pdf
Scientific Misconduct Check 57925-Bing-Yan JP-1.png
Scientific Misconduct Check 57925-Scientific misconduct check.pdf
Scientific Editor Work List 57925-Scientific editor work list.pdf