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12/27/2020 5:30:53 AM | Browse: 539 | Download: 1226
Publication Name World Journal of Stem Cells
Manuscript ID 57934
Country/Territory Spain
Received
2020-06-29 21:31
Peer-Review Started
2020-06-29 21:31
To Make the First Decision
Return for Revision
2020-09-24 19:47
Revised
2020-10-07 20:01
Second Decision
2020-11-11 09:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-12 17:00
Articles in Press
2020-11-12 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-27 08:38
Typeset the Manuscript
2020-12-17 10:19
Publish the Manuscript Online
2020-12-27 05:30
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Review
Article Title Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
Manuscript Source Invited Manuscript
All Author List Alberto González-González, Daniel García-Sánchez, Monica Dotta, José C Rodríguez-Rey and Flor M Pérez-Campo
ORCID
Author(s) ORCID Number
Alberto González-González http://orcid.org/0000-0002-2336-8284
Daniel García-Sánchez http://orcid.org/0000-0002-1754-9185
Monica Dotta http://orcid.org/0000-0003-2719-0564
José C Rodríguez-Rey http://orcid.org/0000-0002-8369-3118
Flor M Pérez-Campo http://orcid.org/0000-0002-9872-7990
Funding Agency and Grant Number
Funding Agency Grant Number
Spanish Ministerio de Economía y competitividad No. RTI2018-097324
Predoctoral program in Biomedicine from the University of Cantabria and the Instituto de Investigación Valdecilla (IDIVAL) No. PREVAL 19/02 and PREVAL 20/01
Corresponding Author Flor M Pérez-Campo, BSc, MSc, PhD, Assistant Professor, Senior Scientist, Department of Molecular Biology_IDIVAL, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es
Key Words Mesenchymal stem cells; Secretome; Soluble factors; Extra-cellular vesicles; Exosomes; Bone regeneration
Core Tip Mesenchymal stem cells (MSCs) produce a high number of bioactive molecules and extracellular vesicles, known as secretome, which exert important paracrine effects upon neighboring cells and tissues. The use of MSCs secretome in tissue regeneration therapies would circumvent the problems linked to MSCs-based therapies, such as the low cell survival and engraftment, which importantly limit their therapeutic efficacy, or the negative side effects associated to the administration of these cells.
Publish Date 2020-12-27 05:30
Citation González-González A, García-Sánchez D, Dotta M, Rodríguez-Rey JC, Pérez-Campo FM. Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine. World J Stem Cells 2020; 12(12): 1529-1552
URL https://www.wjgnet.com/1948-0210/full/v12/i12/1529.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i12.1529
Full Article (PDF) WJSC-12-1529.pdf
Full Article (Word) WJSC-12-1529.docx
Manuscript File 57934_Auto_Edited-Webster J.docx
Answering Reviewers 57934-Answering reviewers.pdf
Audio Core Tip 57934-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 57934-Conflict-of-interest statement.pdf
Copyright License Agreement 57934-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 57934-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 57934-Language certificate.pdf
Peer-review Report 57934-Peer-review(s).pdf
Scientific Misconduct Check 57934-Bing-Fan JR-2.png
Scientific Misconduct Check 57934-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 57934-Scientific misconduct check.pdf
Scientific Editor Work List 57934-Scientific editor work list.pdf