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Articles Published Processes
12/27/2020 5:30:53 AM | Browse: 726 | Download: 1716
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Received |
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2020-06-29 21:31 |
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Peer-Review Started |
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2020-06-29 21:31 |
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To Make the First Decision |
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Return for Revision |
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2020-09-24 19:47 |
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Revised |
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2020-10-07 20:01 |
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Second Decision |
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2020-11-11 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-12 17:00 |
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Articles in Press |
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2020-11-12 17:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-27 08:38 |
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Typeset the Manuscript |
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2020-12-17 10:19 |
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Publish the Manuscript Online |
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2020-12-27 05:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alberto González-González, Daniel García-Sánchez, Monica Dotta, José C Rodríguez-Rey and Flor M Pérez-Campo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Spanish Ministerio de Economía y competitividad |
No. RTI2018-097324 |
| Predoctoral program in Biomedicine from the University of Cantabria and the Instituto de Investigación Valdecilla (IDIVAL) |
No. PREVAL 19/02 and PREVAL 20/01 |
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| Corresponding Author |
Flor M Pérez-Campo, BSc, MSc, PhD, Assistant Professor, Senior Scientist, Department of Molecular Biology_IDIVAL, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es |
| Key Words |
Mesenchymal stem cells; Secretome; Soluble factors; Extra-cellular vesicles; Exosomes; Bone regeneration |
| Core Tip |
Mesenchymal stem cells (MSCs) produce a high number of bioactive molecules and extracellular vesicles, known as secretome, which exert important paracrine effects upon neighboring cells and tissues. The use of MSCs secretome in tissue regeneration therapies would circumvent the problems linked to MSCs-based therapies, such as the low cell survival and engraftment, which importantly limit their therapeutic efficacy, or the negative side effects associated to the administration of these cells. |
| Publish Date |
2020-12-27 05:30 |
| Citation |
González-González A, García-Sánchez D, Dotta M, Rodríguez-Rey JC, Pérez-Campo FM. Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine. World J Stem Cells 2020; 12(12): 1529-1552 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i12/1529.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i12.1529 |
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