Publication Name	World Journal of Gastroenterology
Manuscript ID	5850
Country	Canada

Received	2013-09-28 15:50
Peer-Review Started	2013-09-29 12:25
To Make the First Decision	2013-10-14 21:08
Return for Revision	2013-10-16 17:10
Revised	2013-11-13 05:18
Second Decision	2013-12-13 14:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 14:55
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-22 17:23
Publish the Manuscript Online	2014-05-07 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Vitamin D improves inflammatory bowel disease outcomes: Basic science and clinical review
Manuscript Source	Invited Manuscript
All Author List	Krista M Reich, Richard N Fedorak, Karen Madsen and Karen I Kroeker
Funding Agency and Grant Number	Funding Agency Grant Number Center of Excellence for Gastrointestinal to Reich KM Immunity Research (CEGIIR) to Reich KM Alberta Innovates-Health Solutions Inflammatory Bowel Disease Consortium to Reich KM
Corresponding Author	Karen I Kroeker, MD, FRCPC, Assistant Professor, Division of Gastroenterology, University of Alberta, 2-40 Zeidler Ledcor Centre, 130 University Campus, Edmonton, Alberta T6G 2X8, Canada. karen.kroeker@ualberta.ca
Key Words	Vitamin D; Inflammatory bowel disease; Immune response; Inflammation; Cytokines; Supplementation
Core Tip	There is support for the importance of maintaining normal vitamin D levels in inflammatory bowel disease (IBD) patients, demonstrated by its anti-inflammatory actions in the gut. A randomized controlled trial examined the impact of vitamin D supplementation on IBD outcomes and demonstrated a reduced risk of relapse in vitamin D-treated Crohn’s disease patients. Furthermore, vitamin D3 and active vitamin D have been shown to reduce clinical disease activity and improve quality of life in IBD patients. Normalization of vitamin D levels is also associated with a decreased risk for IBD-related surgery. This vitamin has therapeutic benefit in IBD patients.
Publish Date	2014-05-07 10:10
Citation	Reich KM, Fedorak RN, Madsen K, Kroeker KI. Vitamin D improves inflammatory bowel disease outcomes: Basic science and clinical review. World J Gastroenterol 2014; 20(17): 4934-4947
URL	http://www.wjgnet.com/1007-9327/full/v20/i17/4934.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i17.4934

Full Article (PDF)	WJG-20-4934.pdf
Full Article (Word)	WJG-20-4934.doc
Manuscript File	5850-Review.docx
Answering Reviewers	5850-Answering reviewers.pdf
Copyright License Agreement	5850-Copyright assignment.pdf
Peer-review Report	5850-Peer reviews.pdf
Scientific Editor Work List	5850-Scientific editor work list.doc