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Articles Published Processes
10/24/2020 2:27:20 AM | Browse: 1099 | Download: 1916
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Received |
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2020-08-03 17:14 |
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Peer-Review Started |
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2020-08-03 17:14 |
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First Decision by Editorial Office Director |
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2020-08-09 14:17 |
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Return for Revision |
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2020-08-09 14:17 |
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Revised |
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2020-08-21 02:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-09-08 12:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-09-08 20:34 |
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Articles in Press |
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2020-09-08 20:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-10-21 15:10 |
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Publish the Manuscript Online |
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2020-10-24 02:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Review |
| Article Title |
Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Clifford Akateh, Aslam M Ejaz, Timothy Michael Pawlik and Jordan M Cloyd |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jordan M Cloyd, MD, Assistant Professor, Department of Surgery, The Ohio State University, 410 W 10th Ave, N-907, Columbus, OH 43210, United States. jordan.cloyd@osumc.edu |
| Key Words |
Biliary tract cancer; Preoperative therapy; Conversion therapy; Down-staging; Hepatectomy; Liver resection |
| Core Tip |
Liver resection is the primary component of curative-intent treatment for patients with localized intrahepatic cholangiocarcinoma (ICC). However, a majority of patients present with locally advanced disease and even those who undergo resection are at high risk of recurrence. Neoadjuvant therapy may successfully downstage a subset of patients to resectable disease and improve the long-term outcomes of patients treated with multimodality therapy. As such, the benefits of neoadjuvant treatment strategies aimed at down-staging the tumor and increasing resection rates are of great interest. While high-level evidence regarding the efficacy of neoadjuvant therapy in ICC is lacking, emerging evidence from case control series, as well as recent advances in systemic therapies, liver-directed treatments, and targeted therapies based on an improved understanding of cholangiocarcinogenesis have led to increasing interest in its use. |
| Publish Date |
2020-10-24 02:27 |
| Citation |
Akateh C, Ejaz AM, Pawlik TM, Cloyd JM. Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma. World J Hepatol 2020; 12(10): 693-708 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i10/693.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i10.693 |
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