Publication Name	World Journal of Clinical Cases
Manuscript ID	58721
Country	Japan

Received	2020-08-04 12:53
Peer-Review Started	2020-08-04 12:53
To Make the First Decision
Return for Revision	2020-11-03 04:49
Revised	2020-12-03 09:38
Second Decision	2020-12-18 12:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-12-23 05:07
Articles in Press	2020-12-23 05:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-01-13 11:13
Publish the Manuscript Online	2021-01-25 10:52

ISSN	2307-8960 (online)
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Category	Orthopedics
Manuscript Type	Case Report
Article Title	Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Katsuhiro Hayashi, Norio Yamamoto, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Yoshihiro Araki, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano and Hiroyuki Tsuchiya
ORCID	Author(s) ORCID Number Katsuhiro Hayashi http://orcid.org/0000-0001-8665-2154 Norio Yamamoto http://orcid.org/0000-0002-7250-625X Akihiko Takeuchi http://orcid.org/0000-0002-4071-5620 Shinji Miwa http://orcid.org/0000-0002-5962-8287 Kentaro Igarashi http://orcid.org/0000-0003-2278-1736 Yoshihiro Araki http://orcid.org/0000-0001-5783-109X Hirotaka Yonezawa http://orcid.org/0000-0003-0713-0396 Sei Morinaga http://orcid.org/0000-0003-2961-9432 Yohei Asano http://orcid.org/0000-0002-8777-6076 Hiroyuki Tsuchiya http://orcid.org/0000-0003-0730-7921
Funding Agency and Grant Number
Corresponding Author	Katsuhiro Hayashi, MD, PhD, Professor, Department of Orthopaedic Surgery, Kanazawa University, Takaramachi 13-1, Kanazawa 9208641, Japan. khayashi830@gmail.com
Key Words	Hutchinson-Gilford progeria syndrome; Osteosarcoma; Frozen autograft; Biological reconstruction; Case report; Thyroid cancer
Core Tip	We report the first case describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with Hutchinson-Gilford progeria syndrome. This patient had symptoms of HGPS at birth and was diagnosed at 5 years of age. After the diagnosis of osteosarcoma in proximal tibia, a pedicle frozen autograft using liquid nitrogen was performed to cure her osteosarcoma, and limb salvage was achieved 13 years post-operatively. The patient had a number of surgical site complications, such as wound dehiscence, and superficial and deep infections due to vulnerable skin in HGPS. If the megaprosthesis was chosen, infection could not be subsided and an amputation would eventually be done. Even though amputation was selected, a prosthetic leg would not be applicable because of the poor condition of the skin. Cardiovascular disorders did not develop until 24 years of age and thyroid cancer has been successfully managed by surgery and levothyroxine for 13 years. Due to the morphologic characteristics of bone, vulnerable skin condition, and decreased subcutaneous tissue, the treatment strategy for osteosarcoma in HGPS is complicated. A biological reconstruction method is recommended to manage post-operative complications.
Publish Date	2021-01-25 10:52
Citation	Hayashi K, Yamamoto N, Takeuchi A, Miwa S, Igarashi K, Araki Y, Yonezawa H, Morinaga S, Asano Y, Tsuchiya H. Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report. World J Clin Cases 2021; 9(4): 854-863
URL	https://www.wjgnet.com/2307-8960/full/v9/i4/854.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i4.854

Full Article (PDF)	WJCC-9-854.pdf
Full Article (Word)	WJCC-9-854.docx
CARE Checklist–2016	58721-CARE-Checklist–2016-revision.pdf
Manuscript File	58721_Auto_Edited.docx
Answering Reviewers	58721-Answering reviewers.pdf
Audio Core Tip	58721-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	58721-Conflict-of-interest statement.pdf
Copyright License Agreement	58721-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	58721-Informed consent statement.pdf
Peer-review Report	58721-Peer-review(s).pdf
Scientific Misconduct Check	58721-Bing-Yan JP-1.png
Scientific Misconduct Check	58721-Scientific misconduct check.pdf
Scientific Editor Work List	58721-Scientific editor work list.pdf