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Articles Published Processes
1/25/2021 10:52:18 AM | Browse: 515 | Download: 897
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Received |
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2020-08-04 12:53 |
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Peer-Review Started |
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2020-08-04 12:53 |
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To Make the First Decision |
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Return for Revision |
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2020-11-03 04:49 |
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Revised |
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2020-12-03 09:38 |
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Second Decision |
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2020-12-18 12:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-12-23 05:07 |
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Articles in Press |
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2020-12-23 05:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-01-13 11:13 |
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Publish the Manuscript Online |
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2021-01-25 10:52 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Case Report |
| Article Title |
Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Katsuhiro Hayashi, Norio Yamamoto, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Yoshihiro Araki, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano and Hiroyuki Tsuchiya |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Katsuhiro Hayashi, MD, PhD, Professor, Department of Orthopaedic Surgery, Kanazawa University, Takaramachi 13-1, Kanazawa 9208641, Japan. khayashi830@gmail.com |
| Key Words |
Hutchinson-Gilford progeria syndrome; Osteosarcoma; Frozen autograft; Biological reconstruction; Case report; Thyroid cancer |
| Core Tip |
We report the first case describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with Hutchinson-Gilford progeria syndrome. This patient had symptoms of HGPS at birth and was diagnosed at 5 years of age. After the diagnosis of osteosarcoma in proximal tibia, a pedicle frozen autograft using liquid nitrogen was performed to cure her osteosarcoma, and limb salvage was achieved 13 years post-operatively. The patient had a number of surgical site complications, such as wound dehiscence, and superficial and deep infections due to vulnerable skin in HGPS. If the megaprosthesis was chosen, infection could not be subsided and an amputation would eventually be done. Even though amputation was selected, a prosthetic leg would not be applicable because of the poor condition of the skin. Cardiovascular disorders did not develop until 24 years of age and thyroid cancer has been successfully managed by surgery and levothyroxine for 13 years. Due to the morphologic characteristics of bone, vulnerable skin condition, and decreased subcutaneous tissue, the treatment strategy for osteosarcoma in HGPS is complicated. A biological reconstruction method is recommended to manage post-operative complications. |
| Publish Date |
2021-01-25 10:52 |
| Citation |
Hayashi K, Yamamoto N, Takeuchi A, Miwa S, Igarashi K, Araki Y, Yonezawa H, Morinaga S, Asano Y, Tsuchiya H. Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report. World J Clin Cases 2021; 9(4): 854-863 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i4/854.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i4.854 |
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