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Articles Published Processes
10/14/2020 11:33:23 AM | Browse: 769 | Download: 1407
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Received |
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2020-08-07 02:06 |
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Peer-Review Started |
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2020-08-07 02:07 |
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To Make the First Decision |
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Return for Revision |
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2020-08-22 18:04 |
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Revised |
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2020-08-28 08:24 |
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Second Decision |
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2020-09-07 09:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-08 00:44 |
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Articles in Press |
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2020-09-08 00:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-15 07:43 |
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Typeset the Manuscript |
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2020-10-14 00:52 |
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Publish the Manuscript Online |
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2020-10-14 11:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Cao, Xiang-Bing Shu, Zemin Yao, Guang Ji and Li Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81774084 |
| National Natural Science Foundation of China |
81804020 |
| Young Talent Promotion Project of Chinese Medicine Association |
2019-QNRC2-C04 |
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| Corresponding Author |
Li Zhang, MD, PhD, Senior Scientist, Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. zhangli.hl@163.com |
| Key Words |
Vitamin D receptor; Non-alcoholic steatohepatitisq; Vitamin D; Bile acids; Inflammation; Lipid metabolism |
| Core Tip |
Vitamin D receptor (VDR) is a nuclear receptor and proposed as a druggable target for nonalcoholic steatohepatitis (NASH) due to the discovery of vitamin D deficiency in NASH patients. However, vitamin D supplementation has not consistently conferred expected therapeutic benefits. Actually, VDR can interact with other ligands such as bile acids in addition to vitamin D, and its expression can be induced by fatty acids, and insulin. Liver is an heterogenous organ, VDR activation in hepatic macrophages and hepatic stellate cells resulted in attenuation of hepatic inflammation and fibrosis, whereas activation of VDR in hepatocytes could accelerate lipid accumulation. Thus, the multiplicity of VDR ligands, together with the cell type-specificity of VDR activation, must be taken into consideration in assessing the validity of VDR being a potential druggable target for NASH treatment. |
| Publish Date |
2020-10-14 11:33 |
| Citation |
Cao Y, Shu XB, Yao Z, Ji G, Zhang L. Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis? World J Gastroenterol 2020; 26(38): 5812-5821 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i38/5812.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i38.5812 |
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