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12/14/2020 8:10:05 AM | Browse: 587 | Download: 1339
Publication Name World Journal of Gastroenterology
Manuscript ID 58780
Country/Territory China
Received
2020-08-06 13:15
Peer-Review Started
2020-08-06 13:16
To Make the First Decision
Return for Revision
2020-10-18 02:19
Revised
2020-10-31 16:15
Second Decision
2020-11-06 09:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-09 00:58
Articles in Press
2020-11-09 00:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-14 02:13
Typeset the Manuscript
2020-12-10 02:13
Publish the Manuscript Online
2020-12-14 08:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Control Study
Article Title Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Manuscript Source Unsolicited Manuscript
All Author List Jie Yang, Ya-han Zhang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Ji-Bin Liu and Qiang Lu
ORCID
Author(s) ORCID Number
Jie Yang http://orcid.org/0000-0002-6819-146X
Ya-han Zhang http://orcid.org/0000-0002-5168-8082
Jia-Wu Li http://orcid.org/0000-0003-0844-5883
Ying-Yu Shi http://orcid.org/0000-0002-5910-9882
Jia-Yan Huang http://orcid.org/0000-0002-1918-2874
Yan Luo http://orcid.org/0000-0003-2985-1768
Ji-Bin Liu http://orcid.org/0000-0003-2979-9162
Qiang Lu http://orcid.org/0000-0002-4057-1997
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81571697
The Science and Technology Department of Sichuan Province 2017SZ0003 and 2018FZ0044
Corresponding Author Qiang Lu, MD, Professor, Department of Medical Ultrasound, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan Province, China. luqiang@scu.edu.cn
Key Words Combined hepatocellular-cholangiocarcinoma; Contrast-enhanced ultrasound; Liver imaging reporting and data system; Sensitivity; Diagnosis; Liver neoplasms
Core Tip The imaging features of combined hepatocellular-cholangiocarcinoma (CHC) are complicated due to its complex histopathological characteristics. In addition, biopsy may misguide the correct diagnosis of CHC due to sampling error or tissue insufficiency. This study investigated the diagnostic value of the contrast-enhanced ultrasound Liver Imaging Reporting and Data System classification in association with serological tumor markers in differentiating CHC from hepatocellular carcinoma and intrahepatic cholangiocarcinoma. The results showed that the combined diagnostic criteria had high specificity and negative predictive value but low sensitivity for the diagnosis of CHC. These findings could help radiologists and clinical investigators confidently exclude CHC lesions in the clinical setting.
Publish Date 2020-12-14 08:10
Citation Yang J, Zhang YH, Li JW, Shi YY, Huang JY, Luo Y, Liu JB, Lu Q. Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma. World J Gastroenterol 2020; 26(46): 7325-7337
URL https://www.wjgnet.com/1007-9327/full/v26/i46/7325.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i46.7325
Full Article (PDF) WJG-26-7325.pdf
Full Article (Word) WJG-26-7325.docx
STROBE Statement 58780-STROBE-Statement-revision.pdf
Manuscript File 58780-Review-Filipodia.docx
Answering Reviewers 58780-Answering reviewers.pdf
Audio Core Tip 58780-Audio core tip.mp3
Biostatistics Review Certificate 58780-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 58780-Conflict-of-interest statement.pdf
Copyright License Agreement 58780-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 58780-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 58780-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 58780-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 58780-Language certificate.pdf
Supplementary Material 58780-Supplementary material.pdf
Peer-review Report 58780-Peer-review(s).pdf
Scientific Misconduct Check 58780-Scientific misconduct check.pdf
Scientific Editor Work List 58780-Scientific editor work list.pdf