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Articles Published Processes
12/14/2020 8:10:05 AM | Browse: 561 | Download: 1232
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Received |
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2020-08-17 16:32 |
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Peer-Review Started |
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2020-08-17 16:33 |
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To Make the First Decision |
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Return for Revision |
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2020-10-18 00:31 |
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Revised |
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2020-10-27 02:53 |
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Second Decision |
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2020-11-04 10:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-09 00:57 |
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Articles in Press |
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2020-11-09 00:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-14 00:18 |
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Typeset the Manuscript |
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2020-12-10 02:15 |
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Publish the Manuscript Online |
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2020-12-14 08:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Jun Xue, Ju-Qiang Han, Yuan-Chen Zhou, Hong-Ye Peng, Teng-Fei Yin, Kai-Min Li and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project Task Book of Beijing |
Z171100001717008 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Nonobese nonalcoholic fatty liver disease; High-temperature-processed feed; Mild steatosis and early fibrosis; Untargeted metabolomics characteristics; Animal models; Novel pathogenesis for nonalcoholic fatty liver disease |
| Core Tip |
For some patients with normal body mass index and normal serum indexes, liver damage may already exist. In our previous analysis of clinical data and a high-risk factor questionnaire for patients with nonalcoholic fatty liver disease (NAFLD), we found that the body mass index of some patients did not meet the diagnostic criteria for overweight or obesity. The consumption of high-temperature-processed foods such as fried food, hot-pot is closely associated with the occurrence of NAFLD. Dietary intervention to reduce the consumption of such foods can alleviate NAFLD and improve prognosis. For patients with mild liver fat changes and early fibrosis, some clinical equipment and means of diagnosis are prone to misdiagnosis. Untargeted metabolomics can preliminarily explain the difference in liver pathology in the three groups of rats. |
| Publish Date |
2020-12-14 08:10 |
| Citation |
Xue LJ, Han JQ, Zhou YC, Peng HY, Yin TF, Li KM, Yao SK. Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats. World J Gastroenterol 2020; 26(46): 7299-7311 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i46/7299.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i46.7299 |
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