Publication Name	World Journal of Gastroenterology
Manuscript ID	5887
Country	Italy

Received	2013-09-28 18:36
Peer-Review Started	2013-09-29 15:28
To Make the First Decision	2013-11-12 19:23
Return for Revision	2013-11-15 15:18
Revised	2013-11-26 18:45
Second Decision	2013-12-13 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 14:56
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-22 09:45
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Microbiology
Manuscript Type	Topic Highlights
Article Title	Inflammation and colorectal cancer, when microbiota-host mutualism breaks
Manuscript Source	Invited Manuscript
All Author List	Marco Candela, Silvia Turroni, Elena Biagi, Franck Carbonero, Simone Rampelli, Carla Fiorentini and Patrizia Brigidi
Funding Agency and Grant Number
Corresponding Author	Marco Candela, PhD, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. marco.candela@unibo.it
Key Words	Colorectal cancer; Inflammation; Gut microbiome; Co-abundance groups
Core Tip	By performing the co-abundance groups analysis of the publicly available datasets from microbiome surveys in colorectal cancer (CRC) patients, we have been successful in identifying pro-carcinogenic and protective groups of microorganisms, showing the potential to modulate the fate of CRC onset and progression. Possible mechanisms involved in microbiota-dependent carcinogenesis are reviewed, and the central role of inflammation as a trigger forcing the microbiota from a mutualistic configuration to a CRC-promoting asset is discussed. Finally, possible intervention strategies for modulating microbiome in order to preserve its mutualistic configuration along life span are suggested.
Publish Date	2014-01-26 20:08
Citation	Candela M, Turroni S, Biagi E, Carbonero F, Rampelli S, Fiorentini C, Brigidi P. Inflammation and colorectal cancer, when microbiota-host mutualism breaks. World J Gastroenterol 2014; 20(4): 908-922
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/908.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.908

Full Article (PDF)	WJG-20-908.pdf
Full Article (Word)	WJG-20-908.doc
Manuscript File	5887-Review.docx
Answering Reviewers	5887-Answering reviewers.pdf
Copyright License Agreement	5887-Copyright assignment.pdf
Peer-review Report	5887-Peer reviews.pdf
Scientific Editor Work List	5887-Scientific editor work list.doc