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Articles Published Processes
12/4/2020 6:04:55 AM | Browse: 1055 | Download: 3031
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Received |
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2020-08-17 08:33 |
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Peer-Review Started |
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2020-08-17 08:34 |
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First Decision by Editorial Office Director |
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2020-09-12 06:05 |
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Return for Revision |
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2020-09-12 06:05 |
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Revised |
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2020-09-21 10:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-10-10 10:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-10-13 05:12 |
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Articles in Press |
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2020-10-13 05:12 |
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Edit the Manuscript by Language Editor |
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2020-10-18 20:47 |
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Typeset the Manuscript |
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2020-12-03 01:26 |
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Publish the Manuscript Online |
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2020-12-04 06:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Wei, Hui-Fen Wang, Yu Zhang, Yan-Li Zhang, Bing-Yu Niu and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Technology Support Program during “12th Five-Year Plan” Period of China |
2014BAI08B00 |
| Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) |
Z171100001717008 |
| Project “The role of the gut microbiota and metabolites in the pathogenesis of diarrheal-predominant irritable bowel syndrome” of China-Japan Friendship Hospital |
2019-64-K44 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Bile acids; Irritable bowel syndrome; Diarrhea; Visceral hypersensitivity; Microbiota; Dysbiosis |
| Core Tip |
This study comprehensively investigated the fecal bile acids (BAs) profile of irritable bowel syndrome with predominant diarrhea (IBS-D) patients and healthy controls, and the correlations between BAs and clinical characteristics as well as the gut microbiota of IBS-D patients. We found that the composition of fecal BAs in IBS-D patients is featured by increased primary BAs and decreased secondary BAs, which was associated with diarrhea and visceral hypersensitivity. The abnormality of BAs might be induced by dysbiosis in IBS-D patients, especially the reduction of genera in the Ruminococcaceae family, which contains the majority of bacteria that are capable of converting primary BAs into secondary BAs. |
| Publish Date |
2020-12-04 06:04 |
| Citation |
Wei W, Wang HF, Zhang Y, Zhang YL, Niu BY, Yao SK. Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2020; 26(45): 7153-7172 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i45/7153.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i45.7153 |
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