| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Geane Lopes Flores, Jakeline Ribeiro Barbosa, Helena Medina Cruz, Juliana Custódio Miguel, Denise Vigo Potsch, José Henrique Pilotto, Danielle Malta Lima, Jeová Keny Baima Colares, Carlos Eduardo Brandão-Mello, Marcia Maria Amendola Pires, Jurema Corrêa da Mota, Francisco I Bastos, Lia Laura Lewis-Ximenez and Livia Melo Villar |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Council for Scientific and Technological Development (CNPq) |
|
| Foundation for Research Support of the State of Rio de Janeiro (FAPERJ) |
|
|
| Corresponding Author |
Livia Melo Villar, PhD, Research Scientist, Viral Hepatitis Laboratory, FIOCRUZ, Avenida Brasil, 4365, Rio de Janeiro 21040360, Brazil. liviafiocruz@gmail.com |
| Key Words |
Dried blood spot; Electrochemiluminescence; Hepatitis B; Hepatitis C; Key populations; Diagnosis |
| Core Tip |
Dried blood spot (DBS) samples could be key alternatives for serum obtained by venipuncture in order to increase access to diagnosis for hepatitis B and C. DBS samples along with electrochemiluminescence (ECLIA) could speed up results in key populations such as people living with human immunodeficiency virus, individuals with coagulopathies and chronic kidney disease patients. In this study, we found high accuracy for hepatitis B virus (HBV) and hepatitis C virus (HCV) detection using DBS in key populations. It was possible to observe similar hepatitis prevalences, demographic and clinical data related to hepatitis positivity in DBS and serum. DBS along with ECLIA could be used for diagnosis and prevalence studies of HBV and HCV among hard-to-reach populations. |
| Publish Date |
2021-04-16 10:13 |
| Citation |
Flores GL, Barbosa JR, Cruz HM, Miguel JC, Potsch DV, Pilotto JH, Lima DM, Baima Colares JK, Brandão-Mello CE, Pires MMA, da Mota JC, Bastos FI, Lewis-Ximenez LL, Villar LM. Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations. World J Hepatol 2021; 13(4): 504-514 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i4/504.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i4.504 |
