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Articles Published Processes
12/30/2020 1:59:10 PM | Browse: 757 | Download: 1312
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Received |
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2020-09-06 19:09 |
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Peer-Review Started |
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2020-09-03 14:08 |
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To Make the First Decision |
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Return for Revision |
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2020-10-17 23:14 |
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Revised |
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2020-11-01 14:34 |
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Second Decision |
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2020-12-02 10:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-12-06 01:50 |
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Articles in Press |
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2020-12-06 01:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-12-23 04:19 |
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Publish the Manuscript Online |
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2020-12-30 13:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Experimental models of metabolic and alcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Delfin Gerard Buyco, Jasmin Martin, Sookyoung Jeon, Royce Hooks, Chelsea Lin and Rotonya Carr |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rotonya Carr, MD, Assistant Professor, Division of Gastroenterology, University of Pennsylvania, 421 Curie Boulevard 907 Biomedical Research Center, Philadelphia, PA 19104, United States. rotonya.carr@pennmedicine.upenn.edu |
| Key Words |
Non-alcoholic fatty liver disease; Alcoholic liver disease; Non-alcoholic steatohepatitis; Animal models; Insulin resistance; Oxidative stress |
| Core Tip |
Experimental animal and cell culture models have been developed to study the “syndrome of metabolic and alcoholic steatohepatitis” (SMASH), in which concomitant non-alcoholic fatty liver disease and alcoholic liver disease risk factors play a role in liver injury. These models demonstrate that obesity, metabolic syndrome, and alcohol consumption synergistically contribute to lipid dysregulation, oxidative stress, inflammation, and fibrogenesis. The pathogenesis of SMASH in these experimental models is dependent on obesogenic diet composition, alcohol consumption patterns, alcohol dosage, and genetic background. |
| Publish Date |
2020-12-30 13:59 |
| Citation |
Buyco DG, Martin J, Jeon S, Hooks R, Lin C, Carr R. Experimental models of metabolic and alcoholic fatty liver disease. World J Gastroenterol 2021; 27(1): 1-18 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i1/1.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i1.1 |
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