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Articles Published Processes
3/25/2021 6:36:58 AM | Browse: 583 | Download: 909
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Received |
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2020-08-29 04:01 |
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Peer-Review Started |
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2020-08-29 04:01 |
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To Make the First Decision |
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Return for Revision |
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2021-01-07 19:24 |
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Revised |
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2021-01-19 03:24 |
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Second Decision |
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2021-01-29 06:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-26 03:26 |
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Articles in Press |
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2021-02-26 03:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-08 04:28 |
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Typeset the Manuscript |
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2021-03-24 06:11 |
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Publish the Manuscript Online |
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2021-03-25 06:36 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Functional maturation of immature β cells: A roadblock for a stem cell therapy to type 1 diabetes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zi-Yi Sun, Ting-Yan Yu, Fang-Xu Jiang and Wei Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
81471081 |
| Natural Science Foundation of Fujian Province, China |
2019J01010 |
| Xiamen Research Foundation for Science and Technology Project |
3502Z20194037 |
| Scientific Research Foundation for Advanced Talents, Xiang’an Hospital of Xiamen University |
PM201809170005 |
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| Corresponding Author |
Wei Wang, MD, Doctor, Doctor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 Xiang'an East Road, Xiang'an District, Xiamen 361101, Fujian Province, China. wwei19742007@hotmail.com |
| Key Words |
Stem cell therapy; Type 1 diabetes mellitus; β cell; Maturation |
| Core Tip |
Type 1 diabetes is a metabolic disease characterized by absolute lack of insulin. Current insulin replacement therapy supplies insulin in a non-physiological way and is associated with devastating complications. A diabetes stem cell therapy with insulin-producing β-like cells differentiated in vitro from human pluripotent stem cells has recently attracted great interest in the academic community and the general public. Though great progresses have been made, the β-like cells differentiated in vitro differentiation still have many defects. Here we summarize the latest knowledge on β-cell maturation in vivo and in vitro and the vital roles of key molecules in this process, in order to explore the current problems in a diabetes stem cell therapy. |
| Publish Date |
2021-03-25 06:36 |
| Citation |
Sun ZY, Yu TY, Jiang FX, Wang W. Functional maturation of immature β cells: A roadblock for a stem cell therapy to type 1 diabetes. World J Stem Cells 2021; 13(3): 193-207 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i3/193.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i3.193 |
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