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Publication Name World Journal of Gastroenterology
Manuscript ID 5926
Country/Territory Germany
2013-09-28 21:00
Peer-Review Started
2013-09-30 11:04
To Make the First Decision
2013-10-22 16:27
Return for Revision
2013-10-23 12:42
2013-10-25 19:12
Second Decision
2013-11-13 12:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-13 15:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-11-21 18:45
Publish the Manuscript Online
2013-12-11 16:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Between Scylla and Charybdis: The role of the human immune system in the pathogenesis of hepatitis C
Manuscript Source Invited Manuscript
All Author List Ulrich Spengler, Hans Dieter Nischalke, Jacob Nattermann and Christian P Strassburg
Funding Agency and Grant Number
Corresponding Author Ulrich Spengler, MD, PhD, Department of Internal Medicine 1, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. spengler@uni-bonn.de
Key Words Natural killer cells; CD4+ T helper cells; Regulatory T cells; Interferon; Hepatitis C; Hepatic stellate cells; Hepatocytes; Immunoglobulin; Retinoic acid inducible gene-Ⅰ; Toll like receptors
Core Tip This topic highlight on the immunopathogenesis of chronic hepatitis C addresses changes in innate immunity (interferons and natural killer cells), adaptive immunity and immunoregulation (regulatory T cells). Our review provides a succinct but comprehensive overview and presents the concept, that effective antiviral immunity is associated with pronounced acute liver damage, while during chronic infection the arms of immunity will acquire new functions, which will cause and maintain tissue damage. Thus, the immune response becomes part of the mechanisms that eventually lead to progressive inflammation, liver cirrhosis and death in chronic hepatitis C.
Publish Date 2013-12-11 16:13
Citation Spengler U, Nischalke HD, Nattermann J, Strassburg CP. Between Scylla and Charybdis: The role of the human immune system in the pathogenesis of hepatitis C. World J Gastroenterol 2013; 19(44): 7852-7866
Url http://www.wjgnet.com/1007-9327/full/v19/i44/7852.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i44.7852
Full Article (PDF) WJG-19-7852.pdf
Manuscript File 5926-Review.docx
Answering Reviewers 5926-Answering reviewers.pdf
Copyright License Agreement 5926-Copyright assignment.pdf
Peer-review Report 5926-Peer reviews.pdf
Scientific Editor Work List 5926-Scientific editor work list.doc