Publication Name	World Journal of Gastroenterology
Manuscript ID	5926
Country	Germany

Received	2013-09-28 21:00
Peer-Review Started	2013-09-30 11:04
To Make the First Decision	2013-10-22 16:27
Return for Revision	2013-10-23 12:42
Revised	2013-10-25 19:12
Second Decision	2013-11-13 12:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-13 15:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-21 18:45
Publish the Manuscript Online	2013-12-11 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Between Scylla and Charybdis: The role of the human immune system in the pathogenesis of hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Ulrich Spengler, Hans Dieter Nischalke, Jacob Nattermann and Christian P Strassburg
Funding Agency and Grant Number
Corresponding Author	Ulrich Spengler, MD, PhD, Department of Internal Medicine 1, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. spengler@uni-bonn.de
Key Words	Natural killer cells; CD4+ T helper cells; Regulatory T cells; Interferon; Hepatitis C; Hepatic stellate cells; Hepatocytes; Immunoglobulin; Retinoic acid inducible gene-Ⅰ; Toll like receptors
Core Tip	This topic highlight on the immunopathogenesis of chronic hepatitis C addresses changes in innate immunity (interferons and natural killer cells), adaptive immunity and immunoregulation (regulatory T cells). Our review provides a succinct but comprehensive overview and presents the concept, that effective antiviral immunity is associated with pronounced acute liver damage, while during chronic infection the arms of immunity will acquire new functions, which will cause and maintain tissue damage. Thus, the immune response becomes part of the mechanisms that eventually lead to progressive inflammation, liver cirrhosis and death in chronic hepatitis C.
Publish Date	2013-12-11 16:13
Citation	Spengler U, Nischalke HD, Nattermann J, Strassburg CP. Between Scylla and Charybdis: The role of the human immune system in the pathogenesis of hepatitis C. World J Gastroenterol 2013; 19(44): 7852-7866
URL	http://www.wjgnet.com/1007-9327/full/v19/i44/7852.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i44.7852

Full Article (PDF)	WJG-19-7852.pdf
Manuscript File	5926-Review.docx
Answering Reviewers	5926-Answering reviewers.pdf
Copyright License Agreement	5926-Copyright assignment.pdf
Peer-review Report	5926-Peer reviews.pdf
Scientific Editor Work List	5926-Scientific editor work list.doc