Publication Name	World Journal of Clinical Cases
Manuscript ID	59438
Country	China

Received	2020-09-26 06:14
Peer-Review Started	2020-09-18 10:08
To Make the First Decision
Return for Revision	2020-11-23 07:29
Revised	2020-12-06 03:22
Second Decision	2020-12-15 09:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-12-16 21:40
Articles in Press	2020-12-16 21:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-12-29 08:50
Typeset the Manuscript	2021-01-21 02:05
Publish the Manuscript Online	2021-01-25 10:52

ISSN	2307-8960 (online)
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Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Apert syndrome diagnosed by prenatal ultrasound combined with magnetic resonance image and whole exome sequencing: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Chen Lei and Fei-Xiang Huang
ORCID	Author(s) ORCID Number Chen Lei http://orcid.org/0000-0001-8772-2951 Fei-Xiang Huang http://orcid.org/0000-0002-2299-1795
Funding Agency and Grant Number
Corresponding Author	Fei-Xiang Huang, PhD, Associate Chief Physician, Department of Traditional Chinese Medicine, Hangzhou Women’s Hospital, No. 369 Kunpeng Road, Shangcheng District, Hangzhou 310008, Zhejiang Province, China. fxhuang2009@163.com
Key Words	Apert syndrome; Prenatal ultrasound; Magnetic resonance image; Whole exome sequencing; FGFR2; Case report
Core Tip	Apert syndrome (AS) during pregnancy is rare. We present a case of AS diagnosed by prenatal ultrasound combined with magnetic resonance imaging and whole exome sequencing in late pregnancy. Our case also shows that S252W mutation of AS is related to syndactyly, craniofacial dysplasia and syndactyly, and suggests that young paternal age is also related to AS. We reviewed the three-dimensional fetal ultrasound at 23, 5/7 wk of gestation and found some suspicious images such as craniosynostosis and raised forehead. This shows that improved awareness of AS and prenatal imaging are important.
Publish Date	2021-01-25 10:52
Citation	Lei C, Huang FX. Apert syndrome diagnosed by prenatal ultrasound combined with magnetic resonance image and whole exome sequencing: A case report. World J Clin Cases 2021; 9(4): 912-918
URL	https://www.wjgnet.com/2307-8960/full/v9/i4/912.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i4.912

Full Article (PDF)	WJCC-9-912.pdf
Full Article (Word)	WJCC-9-912.docx
CARE Checklist–2016	59438-CARE-Checklist–2016-revision.jpg
Manuscript File	59438_Auto_Edited-Webster J.docx
Answering Reviewers	59438-Answering reviewers.pdf
Audio Core Tip	59438-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	59438-Conflict-of-interest statement.pdf
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Signed Informed Consent Form(s) or Document(s)	59438-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	59438-Language certificate.pdf
Peer-review Report	59438-Peer-review(s).pdf
Scientific Misconduct Check	59438-Scientific misconduct check.pdf
Scientific Editor Work List	59438-Scientific editor work list.pdf
CrossCheck Report	59438-CrossCheck report.pdf