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Articles Published Processes
1/7/2021 10:14:29 AM | Browse: 560 | Download: 1213
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Received |
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2020-09-17 10:14 |
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Peer-Review Started |
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2020-09-17 10:15 |
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To Make the First Decision |
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Return for Revision |
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2020-11-03 21:59 |
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Revised |
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2020-11-08 04:19 |
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Second Decision |
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2020-11-20 09:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-29 22:17 |
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Articles in Press |
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2020-11-29 22:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-12-07 08:23 |
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Typeset the Manuscript |
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2021-01-04 06:11 |
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Publish the Manuscript Online |
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2021-01-07 10:14 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Mining the cancer genome atlas database for tumor mutation burden and their clinical implications in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Yan Zhao, Xi-Zhen Sun and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
No. 2017YFC0910002 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Tumor mutational burden; Gastric cancer; Prognosis; Immune infiltration; microRNA; Immunotherapy |
| Core Tip |
Whether tumor mutation burden (TMB) was associated with favorable prognosis remained controversy in various cancers. Accumulating evidence highlights that it is necessary to explore clinical impact of TMB in gastric cancer (GC). We defined the highest mutation load quintile (top 20%) in GC as the high-TMB group and found that high TMB values were associated with improved clinical outcomes, which might be attributed to the induction of antitumor immune responses in the microenvironment. We developed a miRNA-based signature to predict TMB values, which might serve as a surrogate biomarker for TMB in GC and aid physicians in clinical medical decision-making. |
| Publish Date |
2021-01-07 10:14 |
| Citation |
Zhao DY, Sun XZ, Yao SK. Mining the cancer genome atlas database for tumor mutation burden and their clinical implications in gastric cancer. World J Gastrointest Oncol 2021; 13(1): 37-57 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i1/37.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i1.37 |
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