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Articles Published Processes
3/30/2021 8:56:50 AM | Browse: 480 | Download: 1545
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Received |
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2020-09-19 06:19 |
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Peer-Review Started |
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2020-09-19 06:20 |
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To Make the First Decision |
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Return for Revision |
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2021-01-07 04:51 |
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Revised |
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2021-01-19 16:33 |
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Second Decision |
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2021-01-30 13:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-01 18:33 |
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Articles in Press |
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2021-02-01 18:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-02-07 18:20 |
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Typeset the Manuscript |
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2021-03-03 07:43 |
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Publish the Manuscript Online |
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2021-03-30 08:56 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Case Report |
| Article Title |
Adult onset type 2 familial hemophagocytic lymphohistiocytosis with PRF1 c.65delC/c.163C>T compound heterozygous mutations: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Yi Liu, Yan-Bo Nie, Xue-Jing Chen, Xiao-Hui Gao, Li-Jia Zhai and Feng-Ling Min |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project of Key Talents of Strengthening Health through Science and Education of Yangzhou City, China |
ZDRC201813 |
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| Corresponding Author |
Feng-Ling Min, MD, Chief Doctor, Professor, Department of Hematology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou 225000, Jiangsu Province, China. 1014121694@qq.com |
| Key Words |
Familial hemophagocytic lymphohistiocytosis; Perforin; PRF1 mutation; Late-onset; Case report |
| Core Tip |
In familial hemophagocytic lymphohistiocytosis (FHL), the PRF1: c.163C>T mutation is rare and the clinical features of it have not been reported. We discuss a case of adult onset type 2 FHL with PRF1 c.65delC/c.163C>T compound heterozygous mutations and conduct a predictive analysis of the two mutations’ effects on the function of perforin and onset of the disease. |
| Publish Date |
2021-03-30 08:56 |
| Citation |
Liu XY, Nie YB, Chen XJ, Gao XH, Zhai LJ, Min FL. Adult onset type 2 familial hemophagocytic lymphohistiocytosis with PRF1 c.65delC/c.163C>T compound heterozygous mutations: A case report. World J Clin Cases 2021; 9(10): 2289-2295 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i10/2289.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i10.2289 |
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