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12/4/2020 6:04:55 AM | Browse: 513 | Download: 1292
Publication Name World Journal of Gastroenterology
Manuscript ID 59620
Country/Territory China
Received
2020-09-20 10:19
Peer-Review Started
2020-09-20 10:19
To Make the First Decision
Return for Revision
2020-09-29 23:18
Revised
2020-10-12 03:04
Second Decision
2020-10-29 11:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-02 04:40
Articles in Press
2020-11-02 04:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-11-17 13:26
Typeset the Manuscript
2020-12-03 01:09
Publish the Manuscript Online
2020-12-04 06:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Xi-Zhen Sun, Dong-Yan Zhao, Yuan-Chen Zhou, Qian-Qian Wang, Geng Qin and Shu-Kun Yao
ORCID
Author(s) ORCID Number
Xi-Zhen Sun http://orcid.org/0000-0001-9967-5726
Dong-Yan Zhao http://orcid.org/0000-0002-7026-068X
Yuan-Chen Zhou http://orcid.org/0000-0001-6024-6246
Qian-Qian Wang http://orcid.org/0000-0002-7709-2121
Geng Qin http://orcid.org/0000-0002-1197-2011
Shu-Kun Yao http://orcid.org/0000-0002-8512-2589
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Research and Development Plan for Precision Medicine Research 2017YFC0910002
Corresponding Author Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Key Words Tryptophan metabolism; Colorectal cancer; Kynurenine; Indoles; Microbiota; Colorectal adenoma
Core Tip This study comprehensively assessed the profiles of fecal tryptophan (Trp) metabolism in patients with colorectal cancer (CRC) and to explore the potential correlations between the gut microbiome, intestinal barrier function, tissue kynurenine pathway (KP) and alterations in fecal Trp metabolism. We found that CRC gut Trp metabolism was characterized by a decreased Trp indole pathway, which is positively correlated with bowel gut barrier function, and an increased KP in colon tissue. In addition, the decreased indoles-producing bacteria may lead to downregulation of the Trp indole metabolic pathway, allowing more Trp to be metabolized along the KP.
Publish Date 2020-12-04 06:04
Citation Sun XZ, Zhao DY, Zhou YC, Wang QQ, Qin G, Yao SK. Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer. World J Gastroenterol 2020; 26(45): 7173-7190
URL https://www.wjgnet.com/1007-9327/full/v26/i45/7173.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i45.7173
Full Article (PDF) WJG-26-7173.pdf
Full Article (Word) WJG-26-7173.docx
STROBE Statement 59620-STROBE-Statement-revision.pdf
Manuscript File 59620_Auto_Edited_WangTQ.docx
Answering Reviewers 59620-Answering reviewers.pdf
Audio Core Tip 59620-Audio core tip.m4a
Biostatistics Review Certificate 59620-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59620-Conflict-of-interest statement.pdf
Copyright License Agreement 59620-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59620-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 59620-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 59620-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59620-Language certificate.pdf
Peer-review Report 59620-Peer-review(s).pdf
Scientific Misconduct Check 59620-Bing-Wang JL-1.jpg
Scientific Misconduct Check 59620-Scientific misconduct check.pdf
Scientific Editor Work List 59620-Scientific editor work list.pdf