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Articles Published Processes
12/4/2020 6:04:55 AM | Browse: 663 | Download: 1871
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Received |
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2020-09-20 10:19 |
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Peer-Review Started |
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2020-09-20 10:19 |
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To Make the First Decision |
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Return for Revision |
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2020-09-29 23:18 |
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Revised |
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2020-10-12 03:04 |
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Second Decision |
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2020-10-29 11:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-02 04:40 |
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Articles in Press |
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2020-11-02 04:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-17 13:26 |
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Typeset the Manuscript |
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2020-12-03 01:09 |
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Publish the Manuscript Online |
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2020-12-04 06:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Zhen Sun, Dong-Yan Zhao, Yuan-Chen Zhou, Qian-Qian Wang, Geng Qin and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Plan for Precision Medicine Research |
2017YFC0910002 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Tryptophan metabolism; Colorectal cancer; Kynurenine; Indoles; Microbiota; Colorectal adenoma |
| Core Tip |
This study comprehensively assessed the profiles of fecal tryptophan (Trp) metabolism in patients with colorectal cancer (CRC) and to explore the potential correlations between the gut microbiome, intestinal barrier function, tissue kynurenine pathway (KP) and alterations in fecal Trp metabolism. We found that CRC gut Trp metabolism was characterized by a decreased Trp indole pathway, which is positively correlated with bowel gut barrier function, and an increased KP in colon tissue. In addition, the decreased indoles-producing bacteria may lead to downregulation of the Trp indole metabolic pathway, allowing more Trp to be metabolized along the KP. |
| Publish Date |
2020-12-04 06:04 |
| Citation |
Sun XZ, Zhao DY, Zhou YC, Wang QQ, Qin G, Yao SK. Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer. World J Gastroenterol 2020; 26(45): 7173-7190 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i45/7173.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i45.7173 |
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