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8/29/2014 5:07:00 PM | Browse: 529 | Download: 327
Publication Name World Journal of Gastroenterology
Manuscript ID 5990
Country/Territory United States
Received
2013-09-29 15:06
Peer-Review Started
2013-09-30 13:38
To Make the First Decision
2013-11-13 15:24
Return for Revision
2013-11-14 15:22
Revised
2013-11-27 03:39
Second Decision
2014-02-27 10:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-27 12:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-23 11:49
Publish the Manuscript Online
2014-04-04 15:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Restoring the gut microbiome for the treatment of inflammatory bowel diseases
Manuscript Source Invited Manuscript
All Author List Jessica R Allegretti and Matthew J Hamilton
Funding Agency and Grant Number
Corresponding author Matthew J Hamilton, MD, Division of Gastroenterology, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, United States. mjhamilton@partners.org
Keywords Crohn’s; Ulcerative colitis; Microbiota; Fecal transplantation; Dysbiosis; Pouchitis; Clostridium difficile; Probiotic
Core Tip Advances into the understanding of the pathogenesis of inflammatory bowel diseases (IBD) have highlighted the importance of a dysbiosis in the intestinal microbiome. A perturbed microbiota with loss of colonization resistance is a main driver of Clostridium difficile infection and exciting new data exists that microbial restoration through the use of fecal microbiota transplantation (FMT) is highly successful. Therefore, it is logical to conclude that FMT will have therapeutic efficacy in IBD. Preliminary studies that have evaluated FMT for IBD are reviewed with an emphasis on subpopulations that may benefit the most. The limitations and unknowns for this novel therapy are also discussed.
Publish Date 2014-04-04 15:11
Citation Allegretti JR, Hamilton MJ. Restoring the gut microbiome for the treatment of inflammatory bowel diseases. World J Gastroenterol 2014; 20(13): 3468-3474
Url http://www.wjgnet.com/1007-9327/full/v20/i13/3468.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i13.3468
Full Article (PDF) WJG-20-3468.pdf
Full Article (Word) WJG-20-3468.doc
Manuscript File 5990-Review.docx
Answering Reviewers 5990-Answering reviewers.pdf
Copyright License Agreement 5990-Copyright assignment.pdf
Peer-review Report 5990-Peer review(s).pdf
Scientific Editor Work List 5990-Scientific editor work list.doc