Publication Name	World Journal of Gastroenterology
Manuscript ID	5990
Country	United States

Received	2013-09-29 15:06
Peer-Review Started	2013-09-30 13:38
To Make the First Decision	2013-11-13 15:24
Return for Revision	2013-11-14 15:22
Revised	2013-11-27 03:39
Second Decision	2014-02-27 10:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-27 12:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-23 11:49
Publish the Manuscript Online	2014-04-04 15:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Restoring the gut microbiome for the treatment of inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Jessica R Allegretti and Matthew J Hamilton
Funding Agency and Grant Number
Corresponding Author	Matthew J Hamilton, MD, Division of Gastroenterology, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, United States. mjhamilton@partners.org
Key Words	Crohn’s; Ulcerative colitis; Microbiota; Fecal transplantation; Dysbiosis; Pouchitis; Clostridium difficile; Probiotic
Core Tip	Advances into the understanding of the pathogenesis of inflammatory bowel diseases (IBD) have highlighted the importance of a dysbiosis in the intestinal microbiome. A perturbed microbiota with loss of colonization resistance is a main driver of Clostridium difficile infection and exciting new data exists that microbial restoration through the use of fecal microbiota transplantation (FMT) is highly successful. Therefore, it is logical to conclude that FMT will have therapeutic efficacy in IBD. Preliminary studies that have evaluated FMT for IBD are reviewed with an emphasis on subpopulations that may benefit the most. The limitations and unknowns for this novel therapy are also discussed.
Publish Date	2014-04-04 15:11
Citation	Allegretti JR, Hamilton MJ. Restoring the gut microbiome for the treatment of inflammatory bowel diseases. World J Gastroenterol 2014; 20(13): 3468-3474
URL	http://www.wjgnet.com/1007-9327/full/v20/i13/3468.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i13.3468

Full Article (PDF)	WJG-20-3468.pdf
Full Article (Word)	WJG-20-3468.doc
Manuscript File	5990-Review.docx
Answering Reviewers	5990-Answering reviewers.pdf
Copyright License Agreement	5990-Copyright assignment.pdf
Peer-review Report	5990-Peer review(s).pdf
Scientific Editor Work List	5990-Scientific editor work list.doc