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Articles Published Processes
4/9/2021 9:07:56 AM | Browse: 666 | Download: 1470
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Received |
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2020-10-14 03:09 |
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Peer-Review Started |
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2020-10-10 10:35 |
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To Make the First Decision |
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Return for Revision |
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2021-01-23 20:23 |
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Revised |
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2021-02-05 15:59 |
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Second Decision |
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2021-03-03 12:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-08 03:22 |
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Articles in Press |
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2021-03-08 03:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-23 01:54 |
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Typeset the Manuscript |
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2021-04-02 10:05 |
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Publish the Manuscript Online |
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2021-04-09 09:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic associated fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Luo, Sheng-Zheng Luo, Zi-Xin Xu, Cui Zhou, Zheng-Hong Li, Xiao-Yan Zhou and Ming-Yi Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81770597 |
| Development Program of China during the 13th Five-year Plan Period |
2017ZX10203202003005 |
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| Corresponding Author |
Ming-Yi Xu, MD, Chief Doctor, Professor, Department of Gastroenterology, Shanghai General Hospital, No. 100 Haining Rd, Shanghai 200080, China. xumingyi2014@163.com |
| Key Words |
Metabolic associated fatty liver disease; MiRNA-1297; Exosome; Hepatic stellate cell; PTEN; Liver fibrosis |
| Core Tip |
In this study, the expression of miR-1297 was found obviously increased in exosomes derived from primary hepatocytes. Exosomal miR-1297 from lipotoxic LO2 (a hepatocyte cell line) could promote LX2 (a hepatic stellate cell line) activation and proliferation by regulating the PTEN/PI3K/ATK pathway. Currently, the study between exosomes and metabolic associated fatty liver disease (MAFLD) was very limited. It was the first time that exosomal miR-1297 from lipotoxic hepatocyte was confirmed to accelerate liver fibrosis, the new mechanism may become a promising treatment target for MAFLD. |
| Publish Date |
2021-04-09 09:07 |
| Citation |
Luo X, Luo SZ, Xu ZX, Zhou C, Li ZH, Zhou XY, Xu MY. Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolism associated fatty liver disease. World J Gastroenterol 2021; 27(14): 1419-1434 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i14/1419.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i14.1419 |
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