| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Predictive value of biologic blood concentration on endoscopic inactivity in inflammatory bowel disease: A systematic review
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Ting Cao, Rong Huang, Ke-Fang Jiang, Xue-Hui Qiao, Jing-Jing Wang, Yi-Hong Fan and Yi Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang TCM Science and Technology Project |
2019ZA056 |
| Zhejiang TCM Science and Technology Project |
2016ZA092 |
| Zhejiang TCM Science and Technology Project |
2021ZA057 |
| The National Natural Science Foundation of China |
81473506 |
|
| Corresponding Author |
Yi-Hong Fan, MD, Associate Professor, Chief Doctor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. yhfansjr@163.com |
| Key Words |
Inflammatory bowel disease; Biological blood concentration; Endoscopic inactivity; Infliximab; Adalimumab; Vedolizumab |
| Core Tip |
Deep remission is considered as the primary endpoint of biological therapy in inflammatory bowel disease. However, it is still difficult to determine or predict whether inflammatory bowel diseases (IBDs) patients achieve deep remission or not. Although endoscopic examinations are widely accepted by gastroenterologists as golden standards on evaluating disease states, majority of IBD patients reject frequent invasive examinations. Hence, new methods of early prediction on therapeutic outcomes of IBD patients under biologics are brought forward by gastroenterologists. Biological blood concentration, one of the major monitoring indicators during biological therapy, exhibits enormous tendency to correlate with outcomes of IBD patients. Nonetheless, biological blood concentration is no substitute for endoscopic examinations in detecting deep lesions. By contrast, combination biological blood concentration and endoscopic examinations is conducive to enhance the accuracy of outcome prediction. |
| Publish Date |
2021-03-03 10:02 |
| Citation |
Cao WT, Huang R, Jiang KF, Qiao XH, Wang JJ, Fan YH, Xu Y. Predictive value of biologic blood concentration on endoscopic inactivity in inflammatory bowel disease: A systematic review. World J Gastroenterol 2021; 27(9): 886-907 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i9/886.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i9.886 |
