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Articles Published Processes
3/30/2021 8:56:49 AM | Browse: 485 | Download: 1232
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Received |
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2020-12-11 09:58 |
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Peer-Review Started |
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2020-12-11 09:58 |
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To Make the First Decision |
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Return for Revision |
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2020-12-30 19:39 |
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Revised |
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2021-01-13 12:36 |
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Second Decision |
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2021-02-06 11:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-11 19:38 |
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Articles in Press |
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2021-02-11 19:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-02-18 21:55 |
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Typeset the Manuscript |
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2021-03-03 07:44 |
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Publish the Manuscript Online |
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2021-03-30 08:56 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nucler factor-κB pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sha Liu, Li-Ping Song, Rong-Bin Li, Le-Heng Feng and Hui Zhu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui Zhu, MPhil, Associate Chief Physician, Department of Rheumatism, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital of Southern Medical University, No. 30 Gongyuan Road, Longsha District, Qiqihar 161005, Heilongjiang Province, China. zhuhui0223@163.com |
| Key Words |
Rheumatoid arthritis; Iiguratimod; Macrophage; Polarity; Nuclear factor-κB |
| Core Tip |
Elderly patients with rheumatoid arthritis (RA) with effusion in the joint cavity were were treated by Iguratimod. Compared with before treatment, Disease Activity Score 28 score and Health Assessment Questionnaire score were decreased, the percentage of CD86 and CD64 decreased, the percentage of CD163 and CD 206 increased, interleukin (IL)-6, IL-1β reduced while, transforming growth factor-β and IL-4 rised. IκB expressed more but phosphorylated-IκB expressed less. which suggested that Iguratimod can promote the transformation of monocyte macrophages from M1 type to M2 type in elderly patients with RA by inhibiting nucler factor-κB pathway, thus improving the symptoms of RA. |
| Publish Date |
2021-03-30 08:56 |
| Citation |
Liu S, Song LP, Li RB, Feng LH, Zhu H. Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nucler factor-κB pathway. World J Clin Cases 2021; 9(10): 2181-2191 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i10/2181.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i10.2181 |
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