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Articles Published Processes
4/21/2021 5:56:26 AM | Browse: 1111 | Download: 1892
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Received |
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2020-11-20 03:30 |
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Peer-Review Started |
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2020-11-20 03:30 |
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First Decision by Editorial Office Director |
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2020-12-17 22:45 |
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Return for Revision |
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2020-12-17 22:45 |
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Revised |
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2021-01-29 08:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-03-24 12:11 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-03-25 03:54 |
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Articles in Press |
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2021-03-25 03:54 |
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Edit the Manuscript by Language Editor |
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2021-04-01 21:19 |
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Typeset the Manuscript |
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2021-04-14 00:00 |
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Publish the Manuscript Online |
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2021-04-21 05:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric-ligation-induced gastroduodenal ulcer in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shan Tong, Huan Wang, Li-Sha A, Ta-Na Bai, Ju-Hua Gong, Wen-Jie Jin, Li-Li Dai, Gen-Na Ba, Sung-Bo Cho and Ming-Hai Fu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Mongolian Medicine Food and Drug Source Protection and Utilization Innovation Team” Construction Project |
190301 |
| National Natural Science Foundation of China |
81760765 |
| Inner Mongolia University for Nationalities Doctoral Start-up Grant |
BS412 |
| Inner Mongolia University for Nationalities Doctoral Start-up Grant |
BS413 |
| Mongolian Medicine Engineering Technology Research Centre Open Fund Project |
MDK2017072 |
| Inner Mongolia Autonomous Region Talent Development Fund Project |
RC201802 |
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| Corresponding Author |
Ming-Hai Fu, PhD, Associate Professor, School of Mongolian Medicine, Inner Mongolia University for Nationalities, No. 996 Xilamulun Street, Tongliao 028000, Inner Mongolia Autonomous Region, China. mfu@imun.edu.cn |
| Key Words |
Sulongga-4; Peptic ulcer; Pyloric ligation; Microarray analysis; Inflammatory reaction; Retinol metabolism |
| Core Tip |
Sulongga-4 (SL-4) is a classic herbal formula used in Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis. The present study investigated the protective effects and molecular mechanisms of SL-4 in the pyloric ligation (PL)-induced gastroduodenal ulcers in rats via microarray study. Our results suggest that SL-4 exhibits profound protective effects against PL-induced gastroduodenal ulcers via reducing inflammatory cytokines and elevating gastric acid inhibitory factor expressions. Down-regulation of CYP2b2 and UGT2b1, and up-regulation of A2m and MASP1 are possibly involved in the gastroduodenal ulcer protection mechanism of SL-4. |
| Publish Date |
2021-04-21 05:56 |
| Citation |
Tong S, Wang H, A LS, Bai TN, Gong JH, Jin WJ, Dai LL, Ba GN, Cho SB, Fu MH. Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric-ligation-induced gastroduodenal ulcer in rats. World J Gastroenterol 2021; 27(16): 1770-1784 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i16/1770.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i16.1770 |
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