Publication Name	World Journal of Clinical Cases
Manuscript ID	61104
Country	China

Received	2020-12-08 12:47
Peer-Review Started	2020-12-08 12:49
To Make the First Decision
Return for Revision	2020-12-30 19:45
Revised	2021-01-11 08:18
Second Decision	2021-02-04 08:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-02-04 18:25
Articles in Press	2021-02-04 18:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-02-19 23:57
Typeset the Manuscript	2021-03-14 05:17
Publish the Manuscript Online	2021-04-02 12:29

ISSN	2307-8960 (online)
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Category	Medicine, General & Internal
Manuscript Type	Case Report
Article Title	Biclonal multiple myeloma of immunoglobulin D-λ+λ: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Qiao-Ling He, Shuang-Shuang Meng, Jing-Nan Yang, Hui-Chao Wang, Yan-Min Li, Yu-Xia Li and Xu-Hong Lin
ORCID	Author(s) ORCID Number Qiao-Ling He http://orcid.org/0000-0002-0716-0504 Shuang-Shuang Meng http://orcid.org/0000-0002-4417-784X Jing-Nan Yang http://orcid.org/0000-0002-8245-4836 Hui-Chao Wang http://orcid.org/0000-0002-5273-4749 Yan-Min Li http://orcid.org/0000-0002-0144-2068 Yu-Xia Li http://orcid.org/0000-0002-5935-9486 Xu-Hong Lin http://orcid.org/0000-0002-4802-2044
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81500430 National Natural Science Foundation of China U1304802 Science and Technology Planning Project of Henan Province 192102310045 Science and Technology Planning Project of Henan Province 182102310544 Science and Technology Planning Project of Henan Province 182102310566 Science and Technology Planning Project of Henan Province 182102310573 Henan Medical Science and Technology Tackling Project 2018020320
Corresponding Author	Xu-Hong Lin, MD, Associate Professor, Department of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital of Henan University, No. 115 Ximen Street, Kaifeng 475000, Henan Province, China. 10220017@vip.henu.edu.cn
Key Words	Multiple myeloma; Immunoglobulin D-λ+λ myeloma; Serum protein electrophoresis; Serum immunofixation electrophoresis; Bone marrow histology; Case report
Core Tip	Immunoglobulin D (IgD)-λ+λ myeloma are extremely rare and has a later International Staging System stage at diagnosis. The median survival time is shorter than that of other subtypes, and renal insufficiency is prone to occur at the time of diagnosis. Furthermore, the laboratory examination tends to consider IgD-λ+λ myeloma as other isotypes in that its serum immunofixation electrophoresis shows two bands in the λ region but no responding heavy chain band. Therefore, a more complete serum immunofixation electrophoresis should be conducted to reduce the rate of missed diagnoses.
Publish Date	2021-04-02 12:29
Citation	He QL, Meng SS, Yang JN, Wang HC, Li YM, Li YX, Lin XH. Biclonal multiple myeloma of immunoglobulin D-λ+λ: A case report. World J Clin Cases 2021; 9(11): 2576-2583
URL	https://www.wjgnet.com/2307-8960/full/v9/i11/2576.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i11.2576

Full Article (PDF)	WJCC-9-2576.pdf
Full Article (Word)	WJCC-9-2576.docx
Manuscript File	61104_Auto_Edited_LM_WangTQ.docx
Answering Reviewers	61104-Answering reviewers.pdf
Audio Core Tip	61104-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	61104-Conflict-of-interest statement.pdf
Copyright License Agreement	61104-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	61104-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	61104-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	61104-Language certificate.pdf
Peer-review Report	61104-Peer-review(s).pdf
Scientific Misconduct Check	61104-Scientific misconduct check.pdf
Scientific Editor Work List	61104-Scientific editor work list.pdf
CrossCheck Report	61104-CrossCheck report.pdf