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Articles Published Processes
4/21/2021 5:56:26 AM | Browse: 621 | Download: 1338
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Received |
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2020-12-22 11:56 |
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Peer-Review Started |
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2020-12-22 11:58 |
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To Make the First Decision |
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Return for Revision |
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2021-01-23 06:42 |
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Revised |
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2021-02-04 10:16 |
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Second Decision |
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2021-03-10 10:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-11 03:05 |
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Articles in Press |
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2021-03-11 03:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-29 13:15 |
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Typeset the Manuscript |
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2021-04-19 09:13 |
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Publish the Manuscript Online |
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2021-04-21 05:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Depletion of MRPL35 inhibits the proliferation of gastric carcinoma by regulating downstream signaling protein
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling Yuan, Jia-Xin Li, Yi Yang, Yan Chen, Ting-Ting Ma, Shuang Liang, Yang Bu, Lei Yu and Yi Nan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningxia Natural Science Foundation |
2020AAC03130 |
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| Corresponding Author |
Yi Nan, MD, PhD, Professor, Key Laboratory of Hui Ethnic Medicine Modernization Ministry of Education, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080011@nxmu.edu.cn |
| Key Words |
Gastric carcinoma; MRPL35; Apoptosis; Proliferation; Tissue microarray; Isobaric tags for relative and absolute quantification |
| Core Tip |
MRPL35 is a member of the large subunit family of mitochondrial ribosomal protein. Our results showed that comparing with adjacent tissues, the expression of MRPL35 in gastric carcinoma (GC) tissues was increased significantly, which was related to age, lymph node metastasis, and the stage of pathological tumor node metastasis of GC patients. Knockdown of MRPL35 could inhibit GC cell proliferation, clone formation, tumor formation in BALB/c nude mice, induce apoptosis, reduce the expression of PICK1 and BCL-XL proteins, and increase that of AGR2 protein. These data indicated MRPL35 might be an oncogene and be used as a new therapeutic target for GC. |
| Publish Date |
2021-04-21 05:56 |
| Citation |
Yuan L, Li JX, Yang Y, Chen Y, Ma TT, Liang S, Bu Y, Yu L, Nan Y. Depletion of MRPL35 inhibits the proliferation of gastric carcinoma by regulating downstream signaling protein. World J Gastroenterol 2021; 27(16): 1785-1804 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i16/1785.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i16.1785 |
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