Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	61264
Country	China

Received	2021-03-04 03:34
Peer-Review Started	2021-03-04 03:34
To Make the First Decision
Return for Revision	2021-04-06 01:36
Revised	2021-04-09 15:46
Second Decision	2021-07-05 12:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-05 13:29
Articles in Press	2021-07-05 13:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-12 14:43
Typeset the Manuscript	2021-08-30 08:33
Publish the Manuscript Online	2021-09-10 12:09

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Scoparone inhibits pancreatic cancer through the PI3K/Akt signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Na Li, Fan Yang, Dong-Yan Liu, Jin-Tao Guo, Nan Ge and Si-Yu Sun
ORCID	Author(s) ORCID Number Na Li http://orcid.org/0000-0002-9841-2200 Fan Yang http://orcid.org/0000-0002-5032-6450 Dong-Yan Liu http://orcid.org/0000-0002-3902-9316 Jin-Tao Guo http://orcid.org/0000-0001-5722-6359 Nan Ge http://orcid.org/0000-0002-5764-7054 Si-Yu Sun http://orcid.org/0000-0002-7308-0473
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 817706555 Special Project from the Central Government of Liaoning Province 2018107003 Liaoning Province Medical Science and Technology Achievements Transformation Foundation 2018225120 China Postdoctoral Science Foundation 2020M670101ZX Doctoral Scientific Research Foundation of Liaoning Province 2019-BS-276 Science and Technology Program of Shenyang 19-112-4-103 Youth Support Foundation of China Medical University QGZ2018058 Scientific Fund of Shengjing Hospital 201801 345 Talent Project of Shengjing Hospital 52-30C
Corresponding Author	Si-Yu Sun, MD, PhD, Chief Doctor, Doctor, Doctor, Professor, Department of Gastroenterology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Key Words	Pancreatic cancer; Scoparone; Akt1; PI3K/Akt signaling pathway; Bioinformatics analysis; Xenograft tumor
Core Tip	To explore the potential antitumor effect of scoparone on pancreatic cancer and the possible molecular mechanism. Target genes of scoparone were determined using the bioinformatics and multiplatform analyses. The effect of scoparone on pancreatic cancer cell proliferation, migration, invasion, cell cycle, and apoptosis was detected. The expression of hub genes was detected using quantitative reverse transcription polymerase chain reaction, and western blotting was used to analyze the molecular mechanism. Xenograft tumor model and immunohistochemistry were used to detect proliferation in vivo. Our findings indicated that scoparone inhibited pancreatic cancer cell proliferation, migration and invasion, and induced cell cycle arrest and apoptosis through the PI3K/Akt signaling pathway.
Publish Date	2021-09-10 12:09
Citation	Li N, Yang F, Liu DY, Guo JT, Ge N, Sun SY. Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway. World J Gastrointest Oncol 2021; 13(9): 1164-1183
URL	https://www.wjgnet.com/1948-5204/full/v13/i9/1164.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i9.1164

Full Article (PDF)	WJGO-13-1164.pdf
Full Article (Word)	WJGO-13-1164.docx
The ARRIVE Guidelines	61264-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	61264_Auto_Edited-ZMG_WangTQ.docx
Answering Reviewers	61264-Answering reviewers.pdf
Audio Core Tip	61264-Audio core tip.m4a
Biostatistics Review Certificate	61264-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	61264-Conflict-of-interest statement.pdf
Copyright License Agreement	61264-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	61264-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	61264-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	61264-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	61264-Language certificate.pdf
Peer-review Report	61264-Peer-review(s).pdf
Scientific Misconduct Check	61264-Bing-Wang JL-1.jpg
Scientific Misconduct Check	61264-Scientific misconduct check.pdf
Scientific Editor Work List	61264-Scientific editor work list.pdf
CrossCheck Report	61264-CrossCheck report.pdf