Publication Name	World Journal of Hepatology
Manuscript ID	6139
Country	United States

Received	2013-10-04 21:12
Peer-Review Started	2013-10-05 14:02
First Decision by Editorial Office Director
Return for Revision	2013-11-12 19:16
Revised	2013-12-02 03:01
Publication Fee Transferred
Second Decision by Editor	2013-12-19 13:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-12-19 13:24
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-19 12:31
Publish the Manuscript Online	2014-01-26 15:15

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Redox therapeutics in hepatic ischemia reperfusion injury
Manuscript Source	Invited Manuscript
All Author List	Rakesh P Patel, John D Lang, Alvin B Smith and Jack H Crawford
Funding Agency and Grant Number
Corresponding Author	Jack H Crawford, MD, PhD, Professor, Division of Cardiothoracic Anesthesia, Department of Anesthesiology, University of Alabama Birmingham, 619 19th Street South, JT 845, Birmingham, AL 35249, United States. dunston@uab.edu
Key Words	Ischemia; Reperfusion; Pre-conditioning; Nitrite
Core Tip	Reactive oxygen and nitrogen species play a central role in the pathology of ischemia-reperfusion injury. In this review we discuss the efforts of many groups to trial therapeutics to ameliorate this damage in animal models of disease as well as clinical trials in humans. The failure of some trials has served to highlight the complexity of timing and compartmentalization of Ischemia Reperfusion injury. Finally, we discuss the emerging potential of replenishing nitric oxide by nitrite therapy and the uniquely broad therapeutic profile of nitrite.
Publish Date	2014-01-26 15:15
Citation	Patel RP, Lang JD, Smith AB, Crawford JH. Redox therapeutics in hepatic ischemia reperfusion injury. World J Hepatol 2014; 6(1): 1-8
URL	http://www.wjgnet.com/1948-5182/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i1.1

Manuscript File	6139-Review.docx
Answering Reviewers	6139-Answering reviews.pdf
Copyright License Agreement	6139-Copyright assignment.pdf
Peer-review Report	6139-Peer review(s).pdf
Scientific Editor Work List	6139-Scientific editor work list.doc