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Articles Published Processes
5/26/2021 9:58:01 AM | Browse: 441 | Download: 1038
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Received |
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2020-12-10 15:50 |
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Peer-Review Started |
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2020-12-10 15:50 |
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To Make the First Decision |
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Return for Revision |
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2021-01-07 03:39 |
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Revised |
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2021-01-20 14:50 |
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Second Decision |
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2021-03-24 12:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-24 15:51 |
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Articles in Press |
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2021-03-24 15:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-08 05:28 |
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Typeset the Manuscript |
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2021-05-19 03:26 |
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Publish the Manuscript Online |
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2021-05-26 09:58 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rheumatology |
| Manuscript Type |
Case Report |
| Article Title |
Bone marrow inhibition induced by azathioprine but without mutation in the thiopurine S-methyltransferase pathogenic site: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Shuang Zhou, Yuan-Yue Lu, Yan-Fang Gao, Wen Shao and Jia Yao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jia Yao, MD, Doctor, Doctor, Department of Gastroenterology, Shanxi Bethune Hospital, No. 99 Longcheng Street, Xiaodian District, Taiyuan 030012, Shanxi Province, China. 18535118814@163.com |
| Key Words |
Azathioprine; Thiopurine S-methyltransferase; Bone marrow inhibition; Lupus nephritis; Case report |
| Core Tip |
Thiopurine S-methyltransferase (TPMT) gene polymorphism testing alone cannot fully predict the occurrence of azathioprine (AZA) adverse reactions such as bone marrow inhibition and alopecia. According to the literature mentioned above, nucleoside diphosphate-linked moiety X motif 15 (NUDT 15) and inosine triphosphate pyrophosphatase (ITPA) gene polymorphism tests should also be performed to predict the occurrence of AZA adverse reactions and further guide initial medication. On the other hand, AZA should be used with caution, and whole blood examination and liver and kidney function should be closely monitored during the entire treatment with AZA regardless of the status of TPMT, NUDT 15 and ITPA single nucleotide polymorphisms. |
| Publish Date |
2021-05-26 09:58 |
| Citation |
Zhou XS, Lu YY, Gao YF, Shao W, Yao J. Bone marrow inhibition induced by azathioprine but without mutation in the thiopurine S-methyltransferase pathogenic site: A case report. World J Clin Cases 2021; 9(17): 4230-4237 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i17/4230.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i17.4230 |
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