Publication Name	World Journal of Diabetes
Manuscript ID	61709
Country	China

Received	2020-12-19 05:11
Peer-Review Started	2020-12-18 04:48
To Make the First Decision
Return for Revision	2021-05-03 23:25
Revised	2021-05-15 11:28
Second Decision	2021-06-25 13:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-25 14:05
Articles in Press	2021-06-25 14:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-05 01:47
Typeset the Manuscript	2021-08-01 01:25
Publish the Manuscript Online	2021-08-09 10:25

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Decabromodiphenyl ether causes insulin resistance and glucose and lipid metabolism disorders in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Ayiguli Alimu, Haiqiemuhan Abudureman, Yong-Zhi Wang, Mei-Yan Li, Jia-Sui Wang and Zao-Ling Liu
ORCID	Author(s) ORCID Number Ayiguli Alimu http://orcid.org/0000-0001-6566-8042 Haiqiemuhan Abudureman http://orcid.org/0000-0002-5496-920X Yong-Zhi Wang http://orcid.org/0000-0003-3805-2765 Mei-Yan Li http://orcid.org/0000-0001-7634-9637 Jia-Sui Wang http://orcid.org/0000-0003-3569-6127 Zao-Ling Liu http://orcid.org/0000-0002-5994-2612
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81760596 Natural Science Foundation of Xinjiang Uygur Autonomous Region 2019D01C209
Corresponding Author	Zao-Ling Liu, PhD, Professor, Department of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical University, No. 393, Xinyi Road, Xinshi District, Urumqi 0991, Xinjiang Uygur Autonomous Region, China. 136497460@qq.com
Key Words	Decabromodiphenyl ether; Adipokine; Glucose and lipid metabolism; Protein expression; Messenger ribonucleic acid expression; Insulin resistance
Core Tip	Decabromodiphenyl ether (BDE-209) may be an environmental risk factor leading to obesity. There are limited literature reports on the correlation between BDE-209 and obesity. This type of research began with animal experiments, and the results showed that BDE-209 affects animal body weight, but the direction of the effect is not consistent. This study found that BDE-209 increased the body weight, body fat, and liver tissue weight in mice, which may be related to the activation of peroxisome proliferators activated receptor-γ receptor activity by BDE-209 and the abnormal differentiation of adipocytes. In obese patients, proinflammatory cytokines and interleukin-6 can cause insulin resistance through a variety of mechanisms.
Publish Date	2021-08-09 10:25
Citation	Alimu A, Abudureman H, Wang YZ, Li MY, Wang JS, Liu ZL. Decabromodiphenyl ether causes insulin resistance and glucose and lipid metabolism disorders in mice. World J Diabetes 2021; 12(8): 1267-1281
URL	https://www.wjgnet.com/1948-9358/full/v12/i8/1267.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i8.1267

Full Article (PDF)	WJD-12-1267.pdf
Full Article (Word)	WJD-12-1267.docx
The ARRIVE Guidelines	61709-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	61709_Auto_Edited-ZMG_WangTQ.docx
Answering Reviewers	61709-Answering reviewers.pdf
Audio Core Tip	61709-Audio core tip.m4a
Biostatistics Review Certificate	61709-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	61709-Conflict-of-interest statement.pdf
Copyright License Agreement	61709-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	61709-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	61709-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	61709-Language certificate.pdf
Peer-review Report	61709-Peer-review(s).pdf
Scientific Misconduct Check	61709-Bing Liu M-1.png
Scientific Misconduct Check	61709-Scientific misconduct check.pdf
Scientific Editor Work List	61709-Scientific editor work list.pdf
CrossCheck Report	61709-CrossCheck report.pdf