Publication Name	World Journal of Psychiatry
Manuscript ID	61711
Country	Denmark

Received	2021-02-01 14:18
Peer-Review Started	2021-02-01 14:20
To Make the First Decision
Return for Revision	2021-07-28 21:58
Revised	2021-08-07 08:40
Second Decision	2022-01-13 05:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-14 06:32
Articles in Press	2022-01-14 06:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-12-19 01:10
Typeset the Manuscript	2022-02-09 08:05
Publish the Manuscript Online	2022-02-17 08:22

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Review
Article Title	Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence
Manuscript Source	Invited Manuscript
All Author List	Filip S Polli and Kristi A Kohlmeier
ORCID	Author(s) ORCID Number Filip S Polli http://orcid.org/0000-0002-3854-9918 Kristi A Kohlmeier http://orcid.org/0000-0003-0183-3816
Funding Agency and Grant Number
Corresponding Author	Kristi A Kohlmeier, PhD, Associate Professor, Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark. kak1@sund.ku.dk
Key Words	Prenatal nicotine exposure; Pregnancy outcome; Addiction risk; Laterodorsal tegmentum; Arousal; Attention
Core Tip	Offspring of women who used nicotine-containing products while pregnant exhibit risk factors for later-life development of cognitive deficits, including attention deficit/hyperactivity disorder and drug dependence. This suggests that circuits that play a role in cognition are being altered by nicotine. The laterodorsal tegmental nucleus of the pons plays a role in attention, motivation, and other cognitive-related processes, and nicotine during gestation has been shown in animal studies to alter functioning of this nucleus. In this review, we discuss the human and animal literature that indicate that alterations in functioning of the laterodorsal tegmental nucleus could arise following prenatal nicotine exposure, and that these alterations could play a role in the negative risks associated with early-life nicotine exposure.
Publish Date	2022-02-17 08:22
Citation	Polli FS, Kohlmeier KA. P Prenatal nicotine alters development of the laterodorsal tegmentum: Possible role for attention-deficit/hyperactivity disorder and drug dependence. World J Psychiatr 2022; 12(2): 212-235
URL	https://www.wjgnet.com/2220-3206/full/v12/i2/212.htm
DOI	https://dx.doi.org/10.5498/wjp.v12.i2.212

Full Article (PDF)	WJP-12-212.pdf
Full Article (Word)	WJP-12-212.docx
Manuscript File	61711_Auto_Edited-YJM-FilipodiaCL.docx
Answering Reviewers	61711-Answering reviewers.pdf
Audio Core Tip	61711-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	61711-Conflict-of-interest statement.pdf
Copyright License Agreement	61711-Copyright license agreement.pdf
Peer-review Report	61711-Peer-review(s).pdf
Scientific Editor Work List	61711-Scientific editor work list.pdf