Publication Name	World Journal of Gastroenterology
Manuscript ID	6174
Country	Japan

Received	2013-10-07 15:33
Peer-Review Started	2013-10-08 09:51
To Make the First Decision	2013-12-04 09:00
Return for Revision	2013-12-04 19:33
Revised	2013-12-11 10:39
Second Decision	2014-01-08 18:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-08 18:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-14 08:24
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Topic Highlights
Article Title	Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Hideya Onishi and Mitsuo Katano
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science, Kakenhi 24390303
Corresponding Author	Hideya Onishi, MD, PhD, Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ohnishi@surg1.med.kyushu-u.ac.jp
Key Words	Hedgehog signaling pathway; Pancreatic cancer; Cancer stem cells; Hypoxic condition; Therapeutic target
Core Tip	Hedgehog (Hh) signaling is involved in the induction of malignant potential in pancreatic cancer, controlling processes of proliferation, invasiveness and tumorigenesis. This phenotypic change is closely associated with the nuclear factor kappa-light-chain-enhancer of activated B cells transcription factor, both in an autocrine and paracrine manner. Hh signaling is also capable of maintaining pancreatic cancer stem cells, and may be activated under conditions of tumor hypoxia. Thus, the Hh signaling pathway may represent a potential therapeutic target for patients with refractory pancreatic cancer and the use of Hh inhibitors will likely play an important role in future therapeutic strategies.
Publish Date	2014-03-06 14:13
Citation	Onishi H, Katano M. Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer. World J Gastroenterol 2014; 20(9): 2335-2342
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2335.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2335

Full Article (PDF)	WJG-20-2335.pdf
Full Article (Word)	WJG-20-2335.doc
Manuscript File	6174-Review.doc
Answering Reviewers	6174-Answering reviewers.pdf
Copyright License Agreement	6174-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20131007093525.pdf
Peer-review Report	6174-Peer review(s).pdf
Scientific Editor Work List	6174-Scientific editor work list.doc