Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	61740
Country	Japan

Received	2020-12-22 05:58
Peer-Review Started	2020-12-22 05:59
To Make the First Decision
Return for Revision	2021-01-07 07:35
Revised	2021-01-22 00:07
Second Decision	2021-02-05 03:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-02-12 15:37
Articles in Press	2021-02-12 15:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-05 04:33
Publish the Manuscript Online	2021-03-08 03:41

ISSN	2219-2808 (online)
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Neonatal cholestasis can be the first symptom of McCune–Albright syndrome: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yoshinori Satomura, Kazuhiko Bessho, Taichi Kitaoka, Shinji Takeyari, Yasuhisa Ohata, Takuo Kubota and Keiichi Ozono
ORCID	Author(s) ORCID Number Yoshinori Satomura http://orcid.org/0000-0002-0083-1774 Kazuhiko Bessho http://orcid.org/0000-0003-1684-2213 Taichi Kitaoka http://orcid.org/0000-0002-3531-884X Shinji Takeyari http://orcid.org/0000-0002-3627-1932 Yasuhisa Ohata http://orcid.org/0000-0001-6084-6620 Takuo Kubota http://orcid.org/0000-0003-4483-4405 Keiichi Ozono http://orcid.org/0000-0002-6517-8825
Funding Agency and Grant Number
Corresponding Author	Kazuhiko Bessho, MD, PhD, Associate Professor, Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Osaka 565-0871, Japan. bessho@ped.med.osaka-u.ac.jp
Key Words	McCune–Albright syndrome; GNAS gene; Neonatal cholestasis; Alagille syndrome; Bile duct paucity; Case report
Core Tip	McCune–Albright syndrome (MAS) is caused by postzygotic somatic mutations of the GNAS gene. It is characterized by the clinical triad of fibrous dysplasia, café-au-lait skin spots, and endocrinological dysfunction. MAS complications other than the triad are also reported. This is the case of a boy with MAS diagnosed with Alagille syndrome in his infancy based on intrahepatic bile duct paucity in liver biopsy, neonatal cholestasis, cardiac manifestation, and renal tubular dysfunction. MAS should be considered as a differential diagnosis for transient cholestasis in infancy.
Publish Date	2021-03-08 03:41
Citation	Satomura Y, Bessho K, Kitaoka T, Takeyari S, Ohata Y, Kubota T, Ozono K. Neonatal cholestasis can be the first symptom of McCune–Albright syndrome: A case report. World J Clin Pediatr 2021; 10(2): 7-14
URL	https://www.wjgnet.com/2219-2808/full/v10/i2/7.htm
DOI	https://dx.doi.org/10.5409/wjcp.v10.i2.7

Full Article (PDF)	WJCP-10-7.pdf
Full Article (Word)	WJCP-10-7.docx
CARE Checklist–2016	61740-CARE-Checklist–2016-revision.pdf
Manuscript File	61740_Auto_Edited_LM.docx
Answering Reviewers	61740-Answering reviewers.pdf
Audio Core Tip	61740-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	61740-Conflict-of-interest statement.pdf
Copyright License Agreement	61740-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	61740-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	61740-Language certificate.pdf
Peer-review Report	61740-Peer-review(s).pdf
Scientific Misconduct Check	61740-Bing-Wang JL-1.jpg
Scientific Misconduct Check	61740-Scientific misconduct check.pdf
Scientific Editor Work List	61740-Scientific editor work list.pdf
CrossCheck Report	61740-CrossCheck report.pdf