Publication Name	World Journal of Hepatology
Manuscript ID	61760
Country	India

Received	2020-12-17 17:36
Peer-Review Started	2020-12-17 17:37
To Make the First Decision
Return for Revision	2021-01-25 03:24
Revised	2021-01-31 10:55
Second Decision	2021-03-02 03:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-03-10 16:36
Articles in Press	2021-03-10 16:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-03-16 12:29
Publish the Manuscript Online	2021-03-20 02:13

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Ramesh Kumar, Utpal Anand and Rajeev Nayan Priyadarshi
ORCID	Author(s) ORCID Number Ramesh Kumar http://orcid.org/0000-0001-5136-4865 Utpal Anand http://orcid.org/0000-0003-0653-4129 Rajeev Nayan Priyadarshi http://orcid.org/0000-0003-2890-8910
Funding Agency and Grant Number
Corresponding Author	Ramesh Kumar, MD, Associate Professor, Department of Gastroenterology, All India Institute of Medical Sciences, Ansari Nagar, Patna 801507, Bihar, India. docrameshkr@gmail.com
Key Words	Lymphatic dysfunction; Cirrhosis; Lymphedema; Lymphangiectasia; Chylous ascites; Refractory ascites
Core Tip	Lymphatic dysfunction appears to play a significant role in the pathophysiology of advanced cirrhosis. Sustained portal hypertension, neurohormonal changes, and low-grade chronic inflammation have been implicated in causing lymphatic dysfunction in advanced cirrhosis, leading to worsening of ascites, lymphedema, and abnormal lipid transport; it also results in increased susceptibility to infections. Chylous ascites and intestinal lymphangiectasia are the rare manifestations of lymphatic dysfunction in cirrhosis, leading to loss of protein, fat, lymphocytes, and immunoglobins, with several clinical consequences. Lymphatic dysfunctions in cirrhosis have been ignored to date; hence, new exploratory research must be undertaken to gain insight into this important subject.
Publish Date	2021-03-20 02:13
Citation	Kumar R, Anand U, Priyadarshi RN. Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications. World J Hepatol 2021; 13(3): 300-314
URL	https://www.wjgnet.com/1948-5182/full/v13/i3/300.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i3.300

Full Article (PDF)	WJH-13-300.pdf
Full Article (Word)	WJH-13-300.docx
Manuscript File	61760_Auto_Edited_LM.docx
Answering Reviewers	61760-Answering reviewers.pdf
Audio Core Tip	61760-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	61760-Conflict-of-interest statement.pdf
Copyright License Agreement	61760-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	61760-Language certificate.pdf
Peer-review Report	61760-Peer-review(s).pdf
Scientific Misconduct Check	61760-Scientific misconduct check.pdf
Scientific Editor Work List	61760-Scientific editor work list.pdf
CrossCheck Report	61760-CrossCheck report.pdf